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Invitrogen
GTSE1 Polyclonal Antibody
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GTSE1 Antibody (PA5-103414) in IHC (P)
Immunohistochemistry analysis of GTSE1 in human pancreatic cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with GTSE1 polyclonal antibody (Product # PA5-103414) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103414
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GTSE1(Accession Q9NYZ3), corresponding to amino acid residues R380-I430.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852757
Product Specific Information
Antibody detects endogenous levels of total GTSE1.
Target Information
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-2 and S-phase expressed 1; G2 and S phase-expressed protein 1; GTSE-1; Protein B99; Protein B99 homolog
Gene Aliases: B99; Gtse-1; GTSE1
UniProt ID: (Human) Q9NYZ3, (Mouse) Q8R080
Entrez Gene ID: (Human) 51512, (Mouse) 29870
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
microtubule-based process
positive regulation of cell migration
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of protein export from nucleus
protein stabilization
positive regulation of protein localization to nucleus
regulation of cell cycle G2/M phase transition
negative regulation of microtubule binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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