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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • GALC Antibodies

          Proteintech

          Galc Polyclonal Antibody

          22 References
          View all (9) GALC antibodies

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          Datasheet
          Protocols
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          Datasheet
          Protocols
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          Cite Galc Polyclonal Antibody

          • Antibody Testing Data (5)
          Galc Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          Galc Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 5

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          Galc Antibody (11991-1-AP) in IHC (P)

          Immunohistochemistry of paraffin-embedded human gliomas using 11991-1-AP (Galc antibody) at dilution of 1:50 (under 10x lens). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Galc Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Galc Antibody in Western Blot (WB)
          Galc Antibody in Western Blot (WB)
          Galc Antibody in Western Blot (WB)
          Galc Antibody in Immunoprecipitation (IP)

          Product Details

          11991-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 8 publications 8 publications

          Immunohistochemistry (IHC)

          -
          View 3 publications 3 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunocytochemistry (ICC/IF)

          -
          View 5 publications 5 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          -

          Miscellaneous PubMed (MISC)

          -
          View 3 publications 3 publications

          Not applicable (N/A)

          -
          View 3 publications 3 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Mouse, Zebrafish

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Galc Fusion Protein Ag3914 (340-513 aa encoded by BC086671)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.34 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          The GALC antibody targets the liposomal enzyme Galactosylceramidase (GALC), which belongs to the glycosyl hydrolase 59 family. Normal GALC mRNA encodes the 80 kDa precursor, which is processed into 50 and 30 kDa subunits.

          Immunogen sequence: YYLKTVGHL EKGGSYVALT DGLGNLTIII ETMSHQHSMC IRPYLPYYNV SHQLATFTLK GSLREIQELQ VWYTKLGTPQ QRLHFKQLDT LWLLDGSGSF TLELEEDEIF TLTTLTTGRK GSYPPPPSSK PFPTNYKDDF NVEYPLFSEA PNFADQTGVF EYYMNNEDRE HRFTL (340-513 aa encoded by BC086671)

          Target Information

          This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: 3.2.1.46; beta-galactosidase; Galactocerebrosidase; Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase; galactosylceraminidase; GALCERase; testis tissue sperm-binding protein Li 88E; testis tissue sperm-binding protein Li 89A

          View more View less

          Gene Aliases: 2310068B06Rik; A930008M05Rik; AW212969; AW413532; Gacy; GALC; twi; twitcher

          View more View less

          UniProt ID: (Human) P54803, (Mouse) P54818

          View more View less

          Entrez Gene ID: (Human) 2581, (Rat) 314360, (Mouse) 14420

          View more View less

          Function(s)
          galactosylceramidase activity
          Process(es)
          carbohydrate metabolic process galactosylceramide catabolic process glycosphingolipid metabolic process
          It has to be done as per old AB suggested Products section.
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