Proteintech

Gelsolin Polyclonal Antibody

Gelsolin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

Gelsolin Antibody (11644-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 11644-2-AP ( Gelsolin Antibody) at dilution of 1:200 (under 40x lens).

Product Image Gallery

Product Details

11644-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Gelsolin Fusion Protein Ag2239 (433-782 aa encoded by BC026033)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAQHGMDD DGTGQKQIWR IEGSNKVPVD PATYGQFYGG DSYIILYNYR HGGRQGQIIY NWQGAQSTQD EVAASAILTA QLDEELGGTP VQSRVVQGKE PAHLMSLFGG KPMIIYKGGT SREGGQTAPA STRLFQVRAN SAGATRAVEV LPKAGALNSN DAFVLKTPSA AYLWVGTGAS EAEKTGAQEL LRVLRAQPVQ VAEGSEPDGF WEALGGKAAY RTSPRLKDKK MDAHPPRLFA CSNKIGRFVI EEVPGELMQE DLATDDVMLL DTWDQVFVWV GKDSQEEEKT EALTSAKRYI ETDPANRDRR TPITVVKQGF EPPSFVGWFL GWDDDYWSVD PLDRAMAELA A (433-782 aa encoded by BC026033)

Target Information

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein.

Genes & development

Norris ML,Mendell JT

Wed Mar 01 00:00:00 UTC 2023

Label-Free Quantification Mass Spectrometry Identifies Protein Markers of Chemotherapy Response in High-Grade Serous Ovarian Cancer.

Cancers

Arentz G,Mittal P,Klingler-Hoffmann M,Condina MR,Ricciardelli C,Lokman NA,Kaur G,Oehler MK,Hoffmann P

Thu Apr 06 00:00:00 UTC 2023

Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea.

Cell reports

Kubota M,Scheibinger M,Jan TA,Heller S

Tue Jan 19 00:00:00 UTC 2021

3'untranslated regions (3'UTR) of Gelsolin mRNA displays anticancer effects in non-small cell lung cancer (NSCLC) cells.

American journal of cancer research

Liu X,Huang X,Ma J,Li L,Hu H,Feng J,Gao X,Zhang Y,Liu L

Thu Sep 16 00:00:00 UTC 2021

3'untranslated regions (3'UTR) of Gelsolin mRNA displays anticancer effects in non-small cell lung cancer (NSCLC) cells.

American journal of cancer research

Liu X,Huang X,Ma J,Li L,Hu H,Feng J,Gao X,Zhang Y,Liu L

Thu Sep 16 00:00:00 UTC 2021

Modification of PLGA Scaffold by MSC-Derived Extracellular Matrix Combats Macrophage Inflammation to Initiate Bone Regeneration via TGF-β-Induced Protein.

Advanced healthcare materials

Deng M,Tan J,Hu C,Hou T,Peng W,Liu J,Yu B,Dai Q,Zhou J,Yang Y,Dong R,Ruan C,Dong S,Xu J

Wed Jul 01 00:00:00 UTC 2020

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring.

Molecular cell

Cagnetta R,Wong HH,Frese CK,Mallucci GR,Krijgsveld J,Holt CE

Thu Feb 07 00:00:00 UTC 2019

Correlation of five secretory proteins with the nasopharyngeal carcinoma metastasis and the clinical applications.

Oncotarget

Tao Y,Wang K,Chen Z,Long L,Wu Q,Cui F,Zhu L,Xiang M,Jiang Y,Liang Y,Qiu S,Xiao Z,Yi B

Tue Apr 25 00:00:00 UTC 2017

Role of gelsolin in cell proliferation and invasion of human hepatocellular carcinoma cells.

Gene

Deng B,Fang J,Zhang X,Qu L,Cao Z,Wang B

Sun Oct 25 00:00:00 UTC 2015

Role of gelsolin in cell proliferation and invasion of human hepatocellular carcinoma cells.

Gene

Deng B,Fang J,Zhang X,Qu L,Cao Z,Wang B

Sun Oct 25 00:00:00 UTC 2015

Role of gelsolin in cell proliferation and invasion of human hepatocellular carcinoma cells.

Gene

Deng B,Fang J,Zhang X,Qu L,Cao Z,Wang B

Sun Oct 25 00:00:00 UTC 2015

Role of gelsolin in cell proliferation and invasion of human hepatocellular carcinoma cells.

Gene

Deng B,Fang J,Zhang X,Qu L,Cao Z,Wang B

Sun Oct 25 00:00:00 UTC 2015

RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wu J,Meng J,Du Y,Huang Y,Jin Y,Zhang J,Wang B,Zhang Y,Sun M,Tang J

Wed May 01 00:00:00 UTC 2013

RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wu J,Meng J,Du Y,Huang Y,Jin Y,Zhang J,Wang B,Zhang Y,Sun M,Tang J

Wed May 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Actin-depolymerizing factor; ADF; ADFBrevin; AGEL; Brevin; DKFZp313L0718; Gelsolin; RP11-477J21.1

View more View less

Gene Aliases: ADF; AGEL; Gsb; GSN

View more View less

UniProt ID: (Human) P06396, (Rat) Q68FP1, (Mouse) P13020

View more View less

Entrez Gene ID: (Human) 2934, (Rat) 296654, (Mouse) 227753

View more View less

Function(s)

actin binding calcium ion binding protein binding protein domain specific binding myosin II binding metal ion binding

Process(es)

phagocytosis, engulfment aging positive regulation of gene expression oligodendrocyte development striated muscle atrophy extracellular matrix disassembly actin filament polymerization protein destabilization tissue regeneration sequestering of actin monomers cellular protein metabolic process actin nucleation response to ethanol negative regulation of viral entry into host cell phosphatidylinositol-mediated signaling actin filament severing barbed-end actin filament capping positive regulation of actin nucleation response to folic acid actin filament capping cilium morphogenesis cellular response to cadmium ion regulation of podosome assembly actin filament reorganization renal protein absorption hepatocyte apoptotic process positive regulation of keratinocyte apoptotic process regulation of wound healing, spreading of epidermal cells regulation of establishment of T cell polarity regulation of plasma membrane raft polarization regulation of receptor clustering positive regulation of protein processing in phagocytic vesicle amyloid fibril formation positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway apoptotic process actin polymerization or depolymerization vesicle-mediated transport regulation of cell adhesion wound healing cell projection organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Gelsolin Polyclonal Antibody

Gelsolin Antibody (11644-2-AP) in IHC (P)

Product Details

11644-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!