Invitrogen

Ghrelin Polyclonal Antibody

Advanced Verification
1 Published Figure
3 References
View all (26) Ghrelin antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA1-1070

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 2 publications 2 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues F(1) N A P F D V G I K L S G A Q Y Q Q H G R A L(23) of the rat Obestatin gene.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1074594

Product Specific Information

PA1-1070 detects Obestatin in mouse and rat samples. This product does not detect endogenous levels of the hormone in rat stomach.

PA1-1070 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~2.5 kDa protein representing synthetic Obestatin.

The PA1-1070 immunogen is a synthetic peptide corresponding to residues F(1) N A P F D V G I K L S G A Q Y Q Q H G R A L(23) of the rat Obestatin gene. This sequence is conserved in mouse and only one amino acid residue difference in human. This peptide (Cat. # PEP-290) is available for use in neutralization and control experiments.

Target Information

GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AMCBX1; Appetite-regulating hormone; FIP-3; FIP3; Fip3p; ghrelin; ghrelin 27; ghrelin 28; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin; ghrelin/obestatin preprohormone; Growth hormone secretagogue; Growth hormone-releasing peptide; IKK-gamma; In2c-preproghrelin; IP; IP1; IP2; IPD2; Motilin-related peptide; NEMO; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; prepro-appetite regulatory hormone; preproghrelin; proghrelin; Protein M46

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Gene Aliases: 2210006E23Rik; Ghr; GHRL; m46; MTLRP; MTLRPAP; UNQ524/PRO1066

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UniProt ID: (Human) Q9UBU3, (Rat) Q9QYH7, (Mouse) Q9EQX0

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Entrez Gene ID: (Human) 51738, (Rat) 59301, (Mouse) 58991

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Function(s)
G-protein coupled receptor binding protein binding growth hormone-releasing hormone activity protein tyrosine kinase activator activity ghrelin receptor binding hormone activity
Process(es)
activation of MAPK activity gastric acid secretion negative regulation of endothelial cell proliferation G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration actin polymerization or depolymerization adult feeding behavior response to hormone hormone-mediated signaling pathway dendrite development positive regulation of insulin secretion regulation of response to food positive regulation of response to food positive regulation of appetite negative regulation of interleukin-1 beta production negative regulation of locomotion regulation of cell proliferation negative regulation of circadian sleep/wake cycle, REM sleep negative regulation of tumor necrosis factor biosynthetic process negative regulation of apoptotic process response to estrogen negative regulation of interleukin-6 biosynthetic process positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of insulin secretion decidualization negative regulation of inflammatory response positive regulation of corticotropin secretion positive regulation of cortisol secretion positive regulation of synapse assembly excitatory postsynaptic potential positive regulation of growth hormone secretion positive regulation of protein tyrosine kinase activity negative regulation of energy homeostasis positive regulation of energy homeostasis glucose metabolic process negative regulation of angiogenesis growth hormone secretion positive regulation of multicellular organism growth cortisol secretion cartilage development positive regulation of growth hormone receptor signaling pathway visual learning
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