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Product Details
X1595P
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to amino acids 345-354 of Gi 1 and 346-355 of Gi 2.
Conjugate
Form
Liquid
Concentration
0.5-2 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: IMR-5 cells or brain.
Target Information
The G protein family of signal transducers includes the alpha, beta, gamma subunits and the effector which are most clearly distinguished by their different alpha chains. The family also includes Gs and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein of unknown function that is abundantly expressed in brain; and transducin 1 and 2, proteins involved in retinal phototransduction. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane-bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); Gi1 protein alpha subunit; GTP-binding protein (G-alpha-i2); GTP-binding regulatory protein Gi alpha-2 chain; guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-1 subunit; guanine nucleotide-binding protein G(i), alpha-2 subunit
Gene Aliases: AU046200; BOS_20921; BOS_4157; BPGTPB; C76432; Galphai2; Gi; Gia; Gialpha1; GIP; Gnai-1; Gnai-2; GNAI1; GNAI2; GNAI2B; H_LUCA15.1; H_LUCA16.1
UniProt ID: (Bovine) P63097, (Human) P63096, (Human) P04899, (Rat) P10824, (Mouse) B2RSH2, (Rat) P04897, (Mouse) P08752
Entrez Gene ID: (Bovine) 281790, (Human) 2770, (Human) 2771, (Bovine) 281791, (Rat) 25686, (Mouse) 14677, (Rat) 81664, (Mouse) 14678
GTPase activity
signal transducer activity
GTP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
metal ion binding
magnesium ion binding
G-protein coupled receptor binding
protein binding
GDP binding
GTPase activating protein binding
nucleotide binding
guanyl nucleotide binding
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
metabolic process
negative regulation of synaptic transmission
cell division
activation of MAPKK activity
adenosine receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
gamma-aminobutyric acid signaling pathway
G-protein coupled glutamate receptor signaling pathway
regulation of heart contraction
cell proliferation
positive regulation of cell proliferation
intracellular signal transduction
regulation of calcium ion transport
protein folding
cell cycle
signal transduction
negative regulation of adenylate cyclase activity
response to nutrient
response to peptide hormone
regulation of cAMP-mediated signaling
cellular response to forskolin
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