Invitrogen

GluR1 Monoclonal Antibody (RH95)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-18117

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
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Immunocytochemistry (ICC/IF)

-
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Product Specifications

Species Reactivity

Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

RH95

Immunogen

Synthetic peptide corresponding to the N-terminal region of rat GRIA1 conjugated to KLH
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

~1.0 mg/mL

Purification

Protein G

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 0.1mg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2539491

Product Specific Information

This antibody contains enough material to conduct 10 mini-Western blots.

Target Information

GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AI853806; AMPA-selective glutamate receptor 1; GluA1; GLUH 1; GluR K1; GluR-1; GluR-A; GluR-K1; GluR1; GluRK1; glutamate receptor; Glutamate receptor 1; glutamate receptor A; Glutamate receptor ionotropic, AMPA 1; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA1 (alpha 1); GPRC1A; Gria 1; GRM1A; HGBR1; HIPA; MGC13325; MGC133252; NMDA1; NMDAR1; NR1; OTTHUMP00000160643; OTTHUMP00000165781; OTTHUMP00000224241; OTTHUMP00000224242; OTTHUMP00000224243; RP11-350O14.1

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Gene Aliases: 2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1; GluR-A; gluR-K1; Glur1; GluRA; Gria1; HIPA1

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UniProt ID: (Rat) P19490, (Mouse) P23818

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Entrez Gene ID: (Rat) 50592, (Mouse) 14799

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Function(s)
G-protein alpha-subunit binding ionotropic glutamate receptor activity AMPA glutamate receptor activity extracellular-glutamate-gated ion channel activity protein binding adenylate cyclase binding protein kinase binding protein domain specific binding PDZ domain binding small GTPase binding myosin V binding G-protein beta-subunit binding beta-2 adrenergic receptor binding identical protein binding protein homodimerization activity protein kinase A binding receptor activity ion channel activity
Process(es)
regulation of receptor recycling chemical synaptic transmission long-term memory response to toxic substance response to lithium ion response to organic cyclic compound neuronal action potential spinal cord development receptor internalization response to estradiol ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic response to cocaine response to drug response to peptide hormone positive regulation of membrane potential response to arsenic-containing substance regulation of synaptic plasticity modulation of synaptic transmission positive regulation of synaptic transmission response to electrical stimulus long term synaptic depression response to fungicide cellular response to amino acid stimulus cellular response to dsRNA cellular response to growth factor stimulus cellular response to peptide hormone stimulus cellular response to organic cyclic compound cellular response to amine stimulus transport ion transport
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