Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
GluR2/GluR3/GluR4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 3
GluR2/GluR3/GluR4 Antibody (PA5-17314) in WB
Western blot analysis was performed on tissue extracts (30 µg lysate) of Mouse Brain (Lane 1), Rat Brain (Lane 2), Mouse Lung (Lane 3), Mouse Kidney (Lane 4), Mouse Skeletal Muscle (Lane 5), Rat Lung (Lane 6) and Rat Kidney (Lane 7). The blot was probed with Anti-GluR2/GluR3/GluR4 Polyclonal Antibody (Product # PA5-17314, 1:1000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 100 kDa band corresponding to G... View More
Product Details
PA5-17314
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Ser720 of human GluR2
Conjugate
Form
Liquid
Concentration
270 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10985891
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; AMPA-selective glutamate receptor 4; dJ1171F9.1; GluA4; GluR-2; GluR-3; GluR-4; GluR-B; GluR-C; GluR-D; GluR-K2; GluR-K3; glutamate receptor; Glutamate receptor 2; Glutamate receptor 3; Glutamate receptor 4; glutamate receptor B; glutamate receptor B flip isoform; glutamate receptor C; glutamate receptor channel alpha 4; glutamate receptor channel alpha3 subunit; Glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; Glutamate receptor ionotropic, AMPA 4; glutamate receptor subunit 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA3 (alpha 3); glutamate receptor, ionotropic, AMPA4 (alpha 4); spike wave 1
Gene Aliases: 2900064I19Rik; GluA2; GluA3; GluA4; Glur-2; GluR-3; Glur-4; GluR-B; GLUR-C; GluR-D; GluR-K2; GLUR-K3; GLUR2; GLUR3; GLUR4; GLUR4C; Gluralpha3; Gluralpha4; GLURB; GLURC; GLURD; GRIA2; GRIA3; GRIA4; HBGR2; Kiaa4184; MRX94; spkw1
UniProt ID: (Human) P42262, (Human) P42263, (Human) P48058, (Rat) P19491, (Mouse) Q9Z2W9, (Rat) P19492, (Mouse) Q9Z2W8, (Rat) P19493
Entrez Gene ID: (Human) 2891, (Human) 2892, (Human) 2893, (Mouse) 14800, (Rat) 29627, (Mouse) 53623, (Rat) 29628, (Mouse) 14802, (Rat) 29629
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
excitatory extracellular ligand-gated ion channel activity
extracellular-glutamate-gated ion channel activity
protein binding
receptor activity
ion channel activity
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
calcium channel regulator activity
signal transduction
chemical synaptic transmission
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
regulation of receptor recycling
transport
ion transport
receptor internalization
synaptic transmission, glutamatergic
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
modulation of synaptic transmission
positive regulation of synaptic transmission, glutamatergic
response to lithium ion
response to fungicide
glutamate receptor signaling pathway
regulation of synapse structure or activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support