AbboMax

GluR6/7 Polyclonal Antibody

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

500-2934

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-

Immunoprecipitation (IP)

2-5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide derived from C-terminus of Glutamate receptor 6/7 Protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

Positive control: Brain

Cellular location: Cytoplasmic, Membrane.

Target Information

Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors, which when activated can activate phopholipases or adenylylcyclase, depending on the neuron.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bA487F5.1; dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); EAA4; EAA5; Excitatory amino acid receptor 4; Excitatory amino acid receptor 5; GluK2; GluK3; gluR beta-2; GluR-6; GluR-7; glutamate receptor; Glutamate receptor 6; Glutamate receptor 7; glutamate receptor beta-2; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic, kainate 2; Glutamate receptor ionotropic, kainate 3; glutamate receptor subunit kainate subtype; glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2; glutamate receptor, ionotropic, kainate 3

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Gene Aliases: 9630027E11; AW124492; EAA4; EAA5; GLR6; GLR7; GluK2; GluK3; GLUK6; Glur-6; Glur-7; GLUR6; GLUR7; GluR7-3; GluR7a; Glurbeta2; GRIK2; GRIK3; MRT6

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UniProt ID: (Human) Q13002, (Human) Q13003, (Rat) P42260, (Rat) P42264, (Mouse) B1AS29

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Entrez Gene ID: (Human) 2898, (Human) 2899, (Rat) 54257, (Mouse) 14806, (Rat) 298521, (Mouse) 14807

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Function(s)
extracellular-glutamate-gated ion channel activity ligand-gated ion channel activity kainate selective glutamate receptor activity PDZ domain binding ubiquitin conjugating enzyme binding ubiquitin protein ligase binding protein homodimerization activity adenylate cyclase inhibiting G-protein coupled glutamate receptor activity G-protein coupled receptor binding ionotropic glutamate receptor activity glutamate receptor activity protein binding identical protein binding receptor activity ion channel activity
Process(es)
signal transduction adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission ion transmembrane transport ionotropic glutamate receptor signaling pathway regulation of membrane potential negative regulation of synaptic transmission, glutamatergic behavioral fear response transport cellular calcium ion homeostasis intracellular protein transport neuronal action potential synaptic transmission, glutamatergic receptor clustering negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process regulation of JNK cascade regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity modulation of synaptic transmission positive regulation of synaptic transmission neuron apoptotic process excitatory postsynaptic potential inhibitory postsynaptic potential ion transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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