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Alomone Labs, LTD
Glucagon Receptor (extracellular) Polyclonal Antibody
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FIGURE: 1 / 2
Glucagon Receptor (extracellular) Antibody (AGR-024-200UL) in IHC (F)
Expression of Glucagon receptor in mouse hypothalamus - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-Glucagon Receptor (extracellular) Antibody (#AGR-024), (1:200), followed by goat- Anti-rabbit-AlexaFluor-488 secondary Antibody . GCGR staining (green) in mouse hypothalamus is detected in neurons (arrows) from the 3rdventricle wall outlining the paraventricular nucle... View More
Product Details
AGR-024-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KTRYSQKIGDDLS, corresponding to amino acid residues 200-212 of rat GCGR, 1st extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Glucagon receptors are G-protein coupled receptors for glucagon and play a central role in the regulation of blood glucose levels and glucose homeostatsis. It regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Glucagon receptors also play an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of down-stream effectors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GL-R; Glucagon receptor; glucagon receptor perhaps same as Niddm3
Gene Aliases: GCGR; GGR; GL-R; GR
UniProt ID: (Human) P47871, (Mouse) Q61606, (Rat) P30082
Entrez Gene ID: (Human) 2642, (Mouse) 14527, (Rat) 24953
exocytosis
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
hormone-mediated signaling pathway
glucose homeostasis
response to starvation
regulation of glycogen metabolic process
cellular response to glucagon stimulus
generation of precursor metabolites and energy
response to nutrient
regulation of blood pressure
positive regulation of GTPase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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