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Invitrogen
Glypican 3 Monoclonal Antibody (9C2)
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Product Details
MA5-17083
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
9C2
Immunogen
Purified recombinant fragment of human GPC3 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538554
Product Specific Information
MA5-17083 targets GPC3 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17083 immunogen is purified recombinant fragment of human GPC3 expressed in E. Coli.
MA5-17083 detects GPC3 which has a predicted molecular weight of approximately 65.5kDa.
Target Information
GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: glypican proteoglycan 3; Glypican-3; GTR2-2; GTR22; heparan sulphate proteoglycan; Intestinal protein OCI-5; MXR7; secreted glypican-3
Gene Aliases: DGSX; GPC3; GTR2-2; MXR7; OCI-5; OCI5; SDYS; SGB; SGBS; SGBS1
UniProt ID: (Human) P51654, (Mouse) Q8CFZ4
Entrez Gene ID: (Human) 2719, (Mouse) 14734
branching involved in ureteric bud morphogenesis
kidney development
negative regulation of cell proliferation
organ morphogenesis
anterior/posterior axis specification
body morphogenesis
negative regulation of peptidase activity
bone mineralization
osteoclast differentiation
lung development
positive regulation of BMP signaling pathway
embryonic hindlimb morphogenesis
regulation of growth
positive regulation of protein catabolic process
positive regulation of endocytosis
negative regulation of smoothened signaling pathway
positive regulation of smoothened signaling pathway
negative regulation of growth
positive regulation of glucose import
negative regulation of epithelial cell proliferation
coronary vasculature development
cell proliferation involved in kidney development
mesenchymal cell proliferation involved in ureteric bud development
mesonephric duct morphogenesis
cell proliferation involved in metanephros development
negative regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway, planar cell polarity pathway
retinoid metabolic process
glycosaminoglycan biosynthetic process
glycosaminoglycan catabolic process
anatomical structure morphogenesis
glycosaminoglycan metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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