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Invitrogen
Growth Hormone Polyclonal Antibody
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Growth Hormone Antibody (PA5-79308) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Growth Hormone in paraffin-embedded section of rat brain tissue using Growth Hormone Polyclonal Antibody (Product # PA5-79308). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dilution o... View More
Product Details
PA5-79308
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived rat GH recombinant protein (Position: F27-F216).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746424
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - IHC: rat brain tissue.
Target Information
Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17. The five genes share a remarkably high degree of sequence identity. Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa. HGH is produced by the somatotroph cells in the pituitary. It acts through binding to membrane receptors that belong to the cytokine receptor subfamily. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Mutations or deletions in the gene lead to growth hormone deficiency and short stature.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Growth hormone; HGH; Somatotropin
Gene Aliases: Gh; Gh1; RNGHGP
UniProt ID: (Rat) P01244
Entrez Gene ID: (Rat) 24391
signal transduction
neuroblast proliferation
female pregnancy
response to light stimulus
response to food
cellular response to insulin stimulus
response to cytokine
regulation of growth
positive regulation of multicellular organism growth
response to peptide hormone
positive regulation of cell differentiation
positive regulation of growth
lung alveolus development
positive regulation of neurogenesis
positive regulation of steroid hormone biosynthetic process
negative regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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