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Invitrogen
H-cadherin Polyclonal Antibody
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Product Details
PA5-36237
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 330-380 of human CDH13
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553431
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 78, 105 and 130 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The protein encoded by this gene has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAD13; cadherin 13, H-cadherin (heart); Cadherin-13; CD39 antigen-like 3; CD39-like 3; CD39L3; ecto-apyrase 3; ecto-ATPase 3; ecto-ATPDase 3; H-cadherin; H-cadherin (heart); HB6; Heart cadherin; heart-cadherin; NTPDase 3; NTPDase-3; P105; T cad; T Cadherin; T-cad; T-cadherin; Truncated cadherin; truncated-cadherin
Gene Aliases: 4932416G01Rik; CDH13; CDHH; Cdht; P105; T-cadherin; Tcad
UniProt ID: (Human) P55290, (Mouse) Q9WTR5
Entrez Gene ID: (Human) 1012, (Rat) 192248, (Mouse) 12554
mitotic cell cycle
positive regulation of endothelial cell proliferation
positive regulation of cell-matrix adhesion
sprouting angiogenesis
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell adhesion
Rho protein signal transduction
negative regulation of cell proliferation
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Rac protein signal transduction
lamellipodium assembly
regulation of endocytosis
positive regulation of cell migration
adherens junction organization
regulation of epidermal growth factor receptor signaling pathway
endothelial cell migration
keratinocyte proliferation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of positive chemotaxis
localization within membrane
low-density lipoprotein particle mediated signaling
regulation of cell growth
cell adhesion
response to organic substance
single organismal cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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