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Product Details
PA5-58200
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human H1FOO. Recombinant protein control fragment (Product #RP-96499).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2642288
Product Specific Information
Immunogen sequence: YRKTKAESKS SKPTASKVKN GAASPTKKKV VAKAKAPKAG QGPNTKAAAP AKGSGSKVVP AHLSRKTEAP KGPRKAGLPI KASSSKVSSQ
Highest antigen sequence identity to the following orthologs: Mouse - 33%, Rat - 36%.
Target Information
Eukaryotic Histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fibers. Two molecules of each of the four core Histones (Histone H2A, H2B, H3, and H4) form the octamer, which consists of two H2A-H2B dimers and two H3-H4 dimers that are nearly symmetrical by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene, that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. H1FOO (H1 histone family, member O, oocyte-specific), also known as OSH1, is a 346 amino acid oocyte-specific Histone that localizes to both the nucleus and the cytoplasm. Expressed as multiple alternatively spliced isoforms, H1FOO is thought to play an important role in gene control during oogenesis and early embryogenesis and is crucial for meiotic maturation of germinal vesicle-stage oocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H1 histone family, member O, oocyte-specific; Histone H1.8; Histone H1oo; Oocyte-specific histone H1; Oocyte-specific linker histone H1; osH1
Gene Aliases: H1-8; H1.8; H1FOO; H1OO; OSH1
UniProt ID: (Human) Q8IZA3
Entrez Gene ID: (Human) 132243
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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