Proteintech

H2AFY2 Polyclonal Antibody

FIGURE: 1 / 4

H2AFY2 Antibody (17030-1-AP) in WB

Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 17030-1-AP (H2AFY2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

H2AFY2 Antibody in Immunoprecipitation (IP)

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Product Details

17030-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

H2AFY2 Fusion Protein Ag10487 (1-372 aa encoded by BC016172)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.32 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSGRSGKKK MSKLSRSARA GVIFPVGRLM RYLKKGTFKY RISVGAPVYM AAVIEYLAAE ILELAGNAAR DNKKARIAPR HILLAVANDE ELNQLLKGVT IASGGVLPRI HPELLAKKRG TKGKSETILS PPPEKRGRKA TSGKKGGKKS KAAKPRTSKK SKPKDSDKEG TSNSTSEDGP GDGFTILSSK SLVLGQKLSL TQSDISHIGS MRVEGIVHPT TAEIDLKEDI GKALEKAGGK EFLETVKELR KSQGPLEVAE AAVSQSSGLA AKFVIHCHIP QWGSDKCEEQ LEETIKNCLS AAEDKKLKSV AFPPFPSGRN CFPKQTAAQV TLKAISAHFD DSSASSLKNV YFLLFDSESI GIYVQEMAKL DAK (1-372 aa encoded by BC016172)

Target Information

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ING4 alleviated lipopolysaccharide-induced inflammation by regulating the NF-κB pathway via a direct interaction with SIRT1.

Immunology and cell biology

Yang Y,Liu Y,He X,Yang F,Han S,Qin A,Wu G,Liu M,Li Z,Wang J,Yang X,Hu D

Sat Feb 01 00:00:00 UTC 2020

ROR alpha protects against LPS-induced inflammation by down-regulating SIRT1/NF-kappa B pathway.

Archives of biochemistry and biophysics

Han S,Li Z,Han F,Jia Y,Qi L,Wu G,Cai W,Xu Y,Li C,Zhang W,Hu D

Sat Jun 15 00:00:00 UTC 2019

MCPIP1 alleviated lipopolysaccharide-induced liver injury by regulating SIRT1 via modulation of microRNA-9.

Journal of cellular physiology

Han S,Li Z,Ji P,Jia Y,Bai X,Cai W,Li X,Yang C,Yang Y,Yang K,Wu G,Zhang W,Hu D

Sun Dec 01 00:00:00 UTC 2019

MCPIP1 regulates RORα expression to protect against liver injury induced by lipopolysaccharide via modulation of miR-155.

Journal of cellular physiology

Li Z,Han S,Jia Y,Yang Y,Han F,Wu G,Li X,Zhang W,Jia W,He X,Han J,Hu D

Sun Sep 01 00:00:00 UTC 2019

Klf4 Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 Induced Protein 1 to Deubiquitinate TRAF6.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Li Z,Jia Y,Han S,Wang X,Han F,Zhang J,Zhang W,Guan H,Hu D

Fri Aug 17 00:00:00 UTC 2018

Klf4 Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 Induced Protein 1 to Deubiquitinate TRAF6.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Li Z,Jia Y,Han S,Wang X,Han F,Zhang J,Zhang W,Guan H,Hu D

Fri Aug 17 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Core histone macro-H2A.2; core histone macroH2A2.2; H2A histone family, member Y2; Histone macroH2A2; histone mH2A2; mH2A2

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Gene Aliases: H2AFY2; H2afy3; MACROH2A2; RGD1561371

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UniProt ID: (Human) Q9P0M6, (Mouse) Q8CCK0

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Entrez Gene ID: (Human) 55506, (Rat) 361844, (Mouse) 404634

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Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding chromatin DNA binding transcription regulatory region DNA binding protein heterodimerization activity molecular_function DNA binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter regulation of cell growth nucleosome assembly chromatin silencing brain development dosage compensation covalent chromatin modification positive regulation of keratinocyte differentiation negative regulation of gene expression, epigenetic establishment of protein localization to chromatin negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter biological_process chromatin modification

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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H2AFY2 Polyclonal Antibody

H2AFY2 Antibody (17030-1-AP) in WB

Product Details

17030-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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