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Isoform 1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3-hydroxyacyl-CoA dehydratase 1; CAP; cementum attachment protein; Cementum-attachment protein; HACD1; protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A; Protein-tyrosine phosphatase-like member A; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1; Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
Gene Aliases: CAP; HACD1; PTPLA
UniProt ID: (Human) B0YJ81
Entrez Gene ID: (Human) 9200
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