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HADH Polyclonal Antibody

HADH Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 17

HADH Antibody (19828-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 19828-1-AP (HADH antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

HADH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HADH Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19828-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 15 publications 15 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HADH Fusion Protein Ag13928 (1-314 aa encoded by BC000306)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAFVTRQFM RSVSSSSTAS ASAKKIIVKH VTVIGGGLMG AGIAQVAAAT GHTVVLVDQT EDILAKSKKG IEESLRKVAK KKFAENPKAG DEFVEKTLST IATSTDAASV VHSTDLVVEA IVENLKVKNE LFKRLDKFAA EHTIFASNTS SLQITSIANA TTRQDRFAGL HFFNPVPVMK LVEVIKTPMT SQKTFESLVD FSKALGKHPV SCKDTPGFIV NRLLVPYLME AIRLYERGDA SKEDIDTAMK LGAGYPMGPF ELLDYVGLDT TKFIVDGWHE MDAENPLHQP SPSLNKLVAE NKFGKKTGEG FYKYK (1-314 aa encoded by BC000306)

Target Information

This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles.

Cell metabolism

Koves TR,Zhang GF,Davidson MT,Chaves AB,Crown SB,Johnson JM,Slentz DH,Grimsrud PA,Muoio DM

Tue Jun 06 00:00:00 UTC 2023

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.

EMBO molecular medicine

Southwell N,Primiano G,Nadkarni V,Attarwala N,Beattie E,Miller D,Alam S,Liparulo I,Shurubor YI,Valentino ML,Carelli V,Servidei S,Gross SS,Manfredi G,Chen Q,D'Aurelio M

Mon Jul 10 00:00:00 UTC 2023

Quantification of Acipimox in Plasma and Tissues by LC-MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia.

Molecules (Basel, Switzerland)

Shen X,Li G,Wang L,Yu H,Zhou L,Deng H,Wang N,Lai C,Zhou W,Gao Y

Wed Sep 28 00:00:00 UTC 2022

A novel isoform of hydroxyacyl-CoA dehydrogenase inhibits cell proliferation.

Biochemical and biophysical research communications

Xia G,Gao Y,Wu C,Pan H,Hou J,Su J,Wei S,Gao X

Sat May 28 00:00:00 UTC 2022

A novel isoform of hydroxyacyl-CoA dehydrogenase inhibits cell proliferation.

Biochemical and biophysical research communications

Xia G,Gao Y,Wu C,Pan H,Hou J,Su J,Wei S,Gao X

Sat May 28 00:00:00 UTC 2022

International journal of molecular sciences

Luo T,Peng J,Li Q,Zhang Y,Huang Y,Xu L,Yang G,Tan D,Zhang Q,Tan Y

Tue Nov 08 00:00:00 UTC 2022

Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen-Glucose Deprivation Conditions.

Journal of proteome research

Wang X,Song T,Sun Y,Men L,Gu Y,Zhang S,Chen X

Fri Jan 01 00:00:00 UTC 2021

Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

Frontiers in oncology

Lu J,Zhang Y,Sun M,Ding C,Zhang L,Kong Y,Cai M,Miccoli P,Ma C,Yue X

Fri Apr 29 00:00:00 UTC 2022

SCF^JFK is functionally linked to obesity and metabolic syndrome.

EMBO reports

He L,Yan R,Yang Z,Zhang Y,Liu X,Yang J,Liu X,Liu X,Xia L,Wang Y,Wu J,Wu X,Shan L,Yang X,Liang J,Shang Y,Sun L

Mon Jul 05 00:00:00 UTC 2021

Insulin resistance is improved in high-fat fed mice by photobiomodulation therapy at 630 nm.

Journal of biophotonics

Silva G,Ferraresi C,de Almeida RT,Motta ML,Paixão T,Ottone VO,Fonseca IA,Oliveira MX,Rocha-Vieira E,Dias-Peixoto MF,Esteves EA,Coimbra CC,Amorim FT,Magalhães FC

Sun Mar 01 00:00:00 UTC 2020

Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle.

Nutrients

Fukazawa A,Koike A,Karasawa T,Tsutsui M,Kondo S,Terada S

Thu Apr 30 00:00:00 UTC 2020

PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.

EBioMedicine

Lyu Z,Mao Z,Li Q,Xia Y,Liu Y,He Q,Wang Y,Zhao H,Lu Z,Zhou Q

Sat Dec 01 00:00:00 UTC 2018

PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.

EBioMedicine

Lyu Z,Mao Z,Li Q,Xia Y,Liu Y,He Q,Wang Y,Zhao H,Lu Z,Zhou Q

Sat Dec 01 00:00:00 UTC 2018

High-Intensity Interval Training Improves Markers of Oxidative Metabolism in Skeletal Muscle of Individuals With Obesity and Insulin Resistance.

Frontiers in physiology

de Matos MA,Vieira DV,Pinhal KC,Lopes JF,Dias-Peixoto MF,Pauli JR,de Castro Magalhães F,Little JP,Rocha-Vieira E,Amorim FT

Thu Oct 01 00:00:00 UTC 2020

Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.

Molecular nutrition & food research

Wu L,Guo X,Hartson SD,Davis MA,He H,Medeiros DM,Wang W,Clarke SL,Lucas EA,Smith BJ,von Lintig J,Lin D

Mon May 01 00:00:00 UTC 2017

Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.

Molecular nutrition & food research

Wu L,Guo X,Hartson SD,Davis MA,He H,Medeiros DM,Wang W,Clarke SL,Lucas EA,Smith BJ,von Lintig J,Lin D

Mon May 01 00:00:00 UTC 2017

Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice.

Scientific reports

Wu L,Guo X,Lyu Y,Clarke SL,Lucas EA,Smith BJ,Hildebrand D,Wang W,Medeiros DM,Shen X,Lin D

Tue Nov 07 00:00:00 UTC 2017

Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice.

Scientific reports

Wu L,Guo X,Lyu Y,Clarke SL,Lucas EA,Smith BJ,Hildebrand D,Wang W,Medeiros DM,Shen X,Lin D

Tue Nov 07 00:00:00 UTC 2017

Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.

Hepatology (Baltimore, Md.)

Martin J,Maurhofer O,Bellance N,Benard G,Graber F,Hahn D,Galinier A,Hora C,Gupta A,Ferrand G,Hoppeler H,Rossignol R,Dufour JF,St-Pierre MV

Wed May 01 00:00:00 UTC 2013

Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.

Hepatology (Baltimore, Md.)

Martin J,Maurhofer O,Bellance N,Benard G,Graber F,Hahn D,Galinier A,Hora C,Gupta A,Ferrand G,Hoppeler H,Rossignol R,Dufour JF,St-Pierre MV

Wed May 01 00:00:00 UTC 2013

Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.

Hepatology (Baltimore, Md.)

Martin J,Maurhofer O,Bellance N,Benard G,Graber F,Hahn D,Galinier A,Hora C,Gupta A,Ferrand G,Hoppeler H,Rossignol R,Dufour JF,St-Pierre MV

Wed May 01 00:00:00 UTC 2013

Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.

Hepatology (Baltimore, Md.)

Martin J,Maurhofer O,Bellance N,Benard G,Graber F,Hahn D,Galinier A,Hora C,Gupta A,Ferrand G,Hoppeler H,Rossignol R,Dufour JF,St-Pierre MV

Wed May 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: HCDH; Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; hydroxylacyl-Coenzyme A dehydrogenase short chain; hydroxylacyl-Coenzyme A dehydrogenase, short chain; hydroxylacyl-Coenzyme A dehydrogenase-dehydrogenase; L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain; M/SCHAD; medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; MGC8392; short chain 3-hydroxyacyl-CoA dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; testis secretory sperm-binding protein Li 203a

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Gene Aliases: AA409008; AU019341; AW742602; HAD; HAD1; HADH; HADH1; HADHSC; HCDH; HHF4; MSCHAD; SCHAD

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UniProt ID: (Human) Q16836, (Mouse) Q61425, (Rat) Q9WVK7

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Entrez Gene ID: (Human) 3033, (Mouse) 15107, (Rat) 113965

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Function(s)

3-hydroxyacyl-CoA dehydrogenase activity NAD+ binding oxidoreductase activity

Process(es)

fatty acid beta-oxidation response to activity response to insulin response to drug negative regulation of insulin secretion lipid metabolic process fatty acid metabolic process oxidation-reduction process response to hormone

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HADH Polyclonal Antibody

HADH Antibody (19828-1-AP) in ICC/IF

Product Details

19828-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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