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Invitrogen
HADHB Polyclonal Antibody
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Product Details
PA5-117024
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 34-270 of human HADHB (NP_0001741)
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901654
Product Specific Information
Positive Samples: BT-474, SW480, HepG2, 293T, Jurkat, Mouse liver, Mouse kidney, Mouse heart, Rat liver
Immunogen sequence: AAPAVQTKTK KTLAKPNIRN VVVVDGVRTP FLLSGTSYKD LMPHDLARAA LTGLLHRTSV PKEVVDYIIF GTVIQEVKTS NVAREAALGA GFSDKTPAHT VTMACISANQ AMTTGVGLIA SGQCDVIVAG GVELMSDVPI RHSRKMRKLM LDLNKAKSMG QRLSLISKFR FNFLAPELPA VSEFSTSETM GHSADRLAAA FAVSRLEQDE YALRSHSLAK KAQDEGLLSD VVPFKVP
Target Information
This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-enoyl-Coenzyme A (CoA) hydratase, beta subunit; 3-ketoacyl-Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein, beta subunit; acetyl-CoA acyltransferase; bet; beta-ketothiolase; hydroxyacyl-Co; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit; mitochondrial trifunctional protein, beta subunit; TP-beta; Trifunctional enzyme subunit beta, mitochondrial
Gene Aliases: 4930479F15Rik; ECHB; HADHB; MSTP029; MTPB; TP-BETA
UniProt ID: (Human) P55084, (Mouse) Q99JY0, (Rat) Q60587
Entrez Gene ID: (Human) 3032, (Mouse) 231086, (Rat) 171155
3-hydroxyacyl-CoA dehydrogenase activity
acetyl-CoA C-acyltransferase activity
enoyl-CoA hydratase activity
protein binding
long-chain-3-hydroxyacyl-CoA dehydrogenase activity
poly(A) RNA binding
fatty-acyl-CoA binding
catalytic activity
long-chain-enoyl-CoA hydratase activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
protein complex binding
NAD binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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