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Immunogen sequence: MPRYTVHVR GEWLAVPCQD AQLTVGWLGR EAVRRYIKNK PDNGGFTSVD DAHFLVRRCK GLGLLDNEDR LEVALENNEF VEVVIEGDAM SPDFIPSQPE GVYLYSKYRE PEKYIELDGD RLTTEDLVNL GKGRYKIKLT PTAEKRVQKS REVIDSIIKE KTVVYGITTG FGKFARTVIP INKLQELQVN LVRSHSSGVG KPLSPERCRM LLALRINVLA KGYSGISLET LKQVIEMFNA SCLPYVPEKG TVGASGDLAP LSHLALGLVG EGKMWSPKSG WADAKYVLEA HGLKPVILKP KEGLALINGT QMITSLGCEA VERASAIARQ ADIVAALTLE VLKGTTKAFD TDIHAL (1-355 aa encoded by B C096097)
HAL is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. HAL defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids.
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Protein Aliases: Histidase; Histidine ammonia-lyase; histidinemia
Gene Aliases: HAL; HIS; histidase; Hsd; HSTD; Huth
UniProt ID: (Human) P42357, (Rat) P21213, (Mouse) P35492
Entrez Gene ID: (Human) 3034, (Rat) 29301, (Mouse) 15109
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