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Product Details
PA5-102436
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human HAMP(Accession P81172), corresponding to amino acid residues A2-M52.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2851841
Product Specific Information
Antibody detects endogenous levels of total HAMP.
Target Information
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hepcidin; hepcidin antimicrobial peptide 1; LEAP-1; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor
Gene Aliases: HAMP; Hamp1; HEPC; Hepc1; HFE2B; LEAP1; PLTR; UNQ487/PRO1003
UniProt ID: (Human) P81172, (Mouse) Q9EQ21, (Rat) Q99MH3
Entrez Gene ID: (Human) 57817, (Mouse) 84506, (Rat) 84604
negative regulation of transcription from RNA polymerase II promoter
cellular iron ion homeostasis
immune response
response to iron ion
killing of cells of other organism
defense response to bacterium
defense response to fungus
multicellular organismal iron ion homeostasis
negative regulation of intestinal absorption
myeloid cell homeostasis
JAK-STAT cascade
negative regulation of iron ion transmembrane transport
positive regulation of macrophage activation
negative regulation of bone resorption
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
iron ion homeostasis
positive regulation of cellular protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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