Invitrogen

HAND1 Polyclonal Antibody

View all (11) HAND1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

720261

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptides corresponding to Human HAND1 (aa 94-105, 173-188)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 0.1% BSA, 30% glycerol

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2633222

Product Specific Information

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.

This antibody is predicted to react with Monkey, Bovine and Rabbit

Target Information

HAND1 belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHa27; Class A basic helix-loop-helix protein 27; eHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; heart and neural crest derivatives expressed transcript 1; Heart- and neural crest derivatives-expressed protein 1; Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast; Th1; Thing-1

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Gene Aliases: BHLHA27; EHAND; Ehand1; HAND1; Hxt; Th1; Thing1

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UniProt ID: (Human) O96004, (Mouse) Q64279, (Rat) P97832

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Entrez Gene ID: (Human) 9421, (Mouse) 15110, (Rat) 59112

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator activity transcription corepressor activity protein binding transcription factor binding enzyme binding identical protein binding protein homodimerization activity bHLH transcription factor binding transcription regulatory region DNA binding protein heterodimerization activity DNA binding sequence-specific DNA binding protein dimerization activity molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis mesoderm formation blastocyst development trophectodermal cell differentiation heart looping embryonic heart tube formation cardiac left ventricle formation cardiac right ventricle formation transcription from RNA polymerase II promoter heart development embryonic heart tube development odontogenesis of dentin-containing tooth negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter ventricular cardiac muscle tissue morphogenesis cardiac septum morphogenesis mesenchyme development cartilage morphogenesis trophoblast giant cell differentiation negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding in utero embryonic development cell fate determination heart morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development cell differentiation positive regulation of transcription, DNA-templated determination of heart left/right asymmetry biological_process
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