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Invitrogen
HAP1 Polyclonal Antibody
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Product Details
PA1-18323
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant rat HAP-1.
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2116130
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HAP-1; HAP-1 antibody; Huntingtin-associated protein 1
Gene Aliases: Hap1; HAP1-A; HAP1-B
UniProt ID: (Rat) P54256
Entrez Gene ID: (Rat) 29430
exocytosis
autophagy
anterograde axonal transport
retrograde axonal transport
protein localization
positive regulation of neuron projection development
protein transport
regulation of exocytosis
cerebellum development
hypothalamus cell differentiation
cell projection organization
neuron projection development
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
positive regulation of synaptic transmission, GABAergic
positive regulation of neurotrophin production
early endosome to late endosome transport
positive regulation of epidermal growth factor receptor signaling pathway
vesicle transport along microtubule
neurotrophin TRK receptor signaling pathway
positive regulation of neurogenesis
cellular response to growth factor stimulus
positive regulation of inclusion body assembly
negative regulation of beta-amyloid formation
regulation of organelle transport along microtubule
positive regulation of nonmotile primary cilium assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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