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Product Details
BS-11696R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HAP40, amino acids 2-80.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Huntington's disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the Huntington protein. Huntington co-purifies with a single novel 40 kDa protein designated HAP40. Recombinant HAP40 is cytoplasmic in the presence of Huntington but is actively targeted to the nucleus in the absence of Huntington. These observations suggest that HAP40 °Contributes to the function of normal Huntington and is a candidate for involvement in the aberrant nuclear localization of mutant Huntington found in degenerating neurons in Huntington's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 40-kDa huntingtin-associated protein; coagulation factor VIII-associated (intronic transcript) 1; coagulation factor VIII-associated (intronic transcript) 2; coagulation factor VIII-associated (intronic transcript) 3; CpG island protein; factor 8-associated gene A; Factor VIII associated protein; Factor VIII intron 22 protein; HAP40; huntingtin-associated protein 40; RP23-114O19.4
Gene Aliases: AI852759; DXS522E; DXUcsf1; F8A; F8A1; F8A2; F8A3; HAP40; RGD1566014
UniProt ID: (Human) P23610, (Mouse) Q00558, (Rat) M0RDU0
Entrez Gene ID: (Human) 8263, (Human) 474383, (Human) 474384, (Mouse) 14070, (Rat) 501661
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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