Proteintech

HAX1 Polyclonal Antibody

HAX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HAX1 Antibody (11266-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using 11266-1-AP (HAX1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

HAX1 Antibody in Immunoprecipitation (IP)

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Product Details

11266-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HAX1 Fusion Protein Ag1792 (1-279 aa encoded by BC014314)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSLFDLFRG FFGFPGPRSH RDPFFGGMTR DEDDDEEEEE EGGSWGRGNP RFHSPQHPPE EFGFGFSFSP GGGIRFHDNF GFDDLVRDFN SIFSDMGAWT LPSHPPELPG PESETPGERL REGQTLRDSM LKYPDSHQPR IFGGVLESDA RSESPQPAPD WGSQRPFHRF DDVWPMDPHP RTREDNDLDS QVSQEGLGPV LQPQPKSYFK SISVTKITKP DGIVEERRTV VDSEGRTETT VTRHEADSSP RGDPESPRPP ALDDAFSILD LFLGRWFRSR (1-279 aa encoded by BC014314)

Target Information

The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.

Journal of oncology

Wang S,Tan J,Chen L,Wang J

Sat Jul 16 00:00:00 UTC 2022

The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly.

Cells

Balcerak A,Macech-Klicka E,Wakula M,Tomecki R,Goryca K,Rydzanicz M,Chmielarczyk M,Szostakowska-Rodzos M,Wisniewska M,Lyczek F,Helwak A,Tollervey D,Kudla G,Grzybowska EA

Tue Sep 20 00:00:00 UTC 2022

The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly.

Cells

Balcerak A,Macech-Klicka E,Wakula M,Tomecki R,Goryca K,Rydzanicz M,Chmielarczyk M,Szostakowska-Rodzos M,Wisniewska M,Lyczek F,Helwak A,Tollervey D,Kudla G,Grzybowska EA

Tue Sep 20 00:00:00 UTC 2022

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.

Molecular cell

Heider M,Eichner R,Stroh J,Morath V,Kuisl A,Zecha J,Lawatscheck J,Baek K,Garz AK,Rudelius M,Deuschle FC,Keller U,Lemeer S,Verbeek M,Götze KS,Skerra A,Weber WA,Buchner J,Schulman BA,Kuster B,Fernández-Sáiz V,Bassermann F

Thu Mar 18 00:00:00 UTC 2021

Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhang Y,Quraishi IH,McClure H,Williams LA,Cheng Y,Kale S,Dempsey GT,Agrawal S,Gerber DJ,McManus OB,Kaczmarek LK

Wed Dec 01 00:00:00 UTC 2021

HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission.

Journal of cellular and molecular medicine

Lin J,Wang Y,Lin Z

Wed Dec 01 00:00:00 UTC 2021

HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission.

Journal of cellular and molecular medicine

Lin J,Wang Y,Lin Z

Wed Dec 01 00:00:00 UTC 2021

Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.

Nature communications

Zhang Y,Varela L,Szigeti-Buck K,Williams A,Stoiljkovic M,Šestan-Peša M,Henao-Mejia J,D'Acunzo P,Levy E,Flavell RA,Horvath TL,Kaczmarek LK

Fri Mar 19 00:00:00 UTC 2021

Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.

Nature communications

Zhang Y,Varela L,Szigeti-Buck K,Williams A,Stoiljkovic M,Šestan-Peša M,Henao-Mejia J,D'Acunzo P,Levy E,Flavell RA,Horvath TL,Kaczmarek LK

Fri Mar 19 00:00:00 UTC 2021

Lamprey PHB2 maintains mitochondrial stability by tanslocation to the mitochondria under oxidative stress.

Fish & shellfish immunology

Shi Y,Li Q,Sun F,Zhu C,Ma S,Qin D,Li Q,Li T

Tue Sep 01 00:00:00 UTC 2020

HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.

Thoracic cancer

Liang Z,Zhong Y,Meng L,Chen Y,Liu Y,Wu A,Li X,Wang M

Sun Nov 01 00:00:00 UTC 2020

HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.

Thoracic cancer

Liang Z,Zhong Y,Meng L,Chen Y,Liu Y,Wu A,Li X,Wang M

Sun Nov 01 00:00:00 UTC 2020

Immunoblotting validation of research antibodies generated against HS1-associated protein X-1 in the human neutrophil model cell line PLB-985.

F1000Research

Cavnar P,Inman K

Wed Jun 29 00:00:00 UTC 2016

Hax1 regulates neutrophil adhesion and motility through RhoA.

The Journal of cell biology

Cavnar PJ,Berthier E,Beebe DJ,Huttenlocher A

Mon May 02 00:00:00 UTC 2011

Hax1 regulates neutrophil adhesion and motility through RhoA.

The Journal of cell biology

Cavnar PJ,Berthier E,Beebe DJ,Huttenlocher A

Mon May 02 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: FLJ17042; FLJ18492; FLJ93803; HAX-1; HCLS1 (and PKD2) associated protein; HCLS1-associated protein X-1; HS1 binding protein; HS1-associated protein X-1; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1; OTTHUMP00000034190; RP11-137P24.1

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Gene Aliases: HAX-1; HAX1; HCLSBP1; HS1BP1; HSP1BP-1; mHAX-1s; SCN3; SIG-111; Silg111

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UniProt ID: (Human) O00165, (Mouse) O35387

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Entrez Gene ID: (Human) 10456, (Mouse) 23897

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Function(s)

protein binding interleukin-1 binding protein N-terminus binding protein domain specific binding

Process(es)

mitochondrion organization positive regulation of phosphatidylinositol 3-kinase signaling regulation of actin filament polymerization positive regulation of granulocyte differentiation positive regulation of peptidyl-serine phosphorylation regulation of apoptotic process negative regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase B signaling cellular response to cytokine stimulus regulation of mitophagy regulation of protein targeting to mitochondrion positive regulation of actin cytoskeleton reorganization cell surface receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HAX1 Polyclonal Antibody

HAX1 Antibody (11266-1-AP) in IHC (P)

Product Details

11266-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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