Proteintech

HBB Polyclonal Antibody

HBB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

HBB Antibody (16216-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver using 16216-1-AP (HBB antibody) at dilution of 1:100 (under 40x lens).

HBB Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16216-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HBB Fusion Protein Ag9216 (1-147 aa encoded by BC007075)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody, raised against the full-length human HBB, recognizes the 13-16 kDa HBB in western blot analyses of human heart and placenta.

Immunogen sequence: MVHLTPEEK SAVTALWGKV NVDEVGGEAL GRLLVVYPWT QRFFESFGDL STPDAVMGNP KVKAHGKKVL GAFSDGLAHL DNLKGTFATL SELHCDKLHV DPENFRLLGN VLVCVLAHHF GKEFTPPVQA AYQKVVAGVA NALAHKYH (1-147 aa encoded by BC007075)

Target Information

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon-gamma-G-gamma-A-delta-beta-3'.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model.

Nature communications

Hu M,Li T,Ma X,Liu S,Li C,Huang Z,Lin Y,Wu R,Wang S,Lu D,Lu T,Men X,Shen S,Huang H,Liu Y,Song K,Jian B,Jiang Y,Qiu W,Liu Q,Lu Z,Cai W

Tue Jul 04 00:00:00 UTC 2023

Identification of potential plasma markers for hepatitis B virus-related chronic hepatitis and liver fibrosis/cirrhosis.

Journal of medical virology

Zhao D,Yu S,Guo P,Zhang X,Tang Y,Dong C,Zhao S,Li L,Al-Dhamin Z,Ai R,Xue N,Dong S,Nan Y

Mon Aug 01 00:00:00 UTC 2022

Hemovasculogenic origin of blood vessels in the developing mouse brain.

The Journal of comparative neurology

Gama Sosa MA,De Gasperi R,Perez GM,Hof PR,Elder GA

Mon Feb 01 00:00:00 UTC 2021

ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription.

eLife

Riou R,Ladli M,Gerbal-Chaloin S,Bossard P,Gougelet A,Godard C,Loesch R,Lagoutte I,Lager F,Calderaro J,Dos Santos A,Wang Z,Verdier F,Colnot S

Wed Oct 21 00:00:00 UTC 2020

ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription.

eLife

Riou R,Ladli M,Gerbal-Chaloin S,Bossard P,Gougelet A,Godard C,Loesch R,Lagoutte I,Lager F,Calderaro J,Dos Santos A,Wang Z,Verdier F,Colnot S

Wed Oct 21 00:00:00 UTC 2020

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

Haematologica

Maio N,Kim KS,Holmes-Hampton G,Singh A,Rouault TA

Sun Sep 01 00:00:00 UTC 2019

Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells.

Stem cells (Dayton, Ohio)

Leung A,Zulick E,Skvir N,Vanuytsel K,Morrison TA,Naing ZH,Wang Z,Dai Y,Chui DHK,Steinberg MH,Sherr DH,Murphy GJ

Sun Jul 01 00:00:00 UTC 2018

A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.

Blood cells, molecules & diseases

Morrison TA,Wilcox I,Luo HY,Farrell JJ,Kurita R,Nakamura Y,Murphy GJ,Cui S,Steinberg MH,Chui DHK

Thu Mar 01 00:00:00 UTC 2018

A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.

Blood cells, molecules & diseases

Morrison TA,Wilcox I,Luo HY,Farrell JJ,Kurita R,Nakamura Y,Murphy GJ,Cui S,Steinberg MH,Chui DHK

Thu Mar 01 00:00:00 UTC 2018

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Thu Jun 02 00:00:00 UTC 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Thu Jun 02 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: beta globin chain; Beta-globin; hemoglobin beta; Hemoglobin beta chain; Hemoglobin subunit beta; hemoglobin, beta

View more View less

Gene Aliases: beta-globin; CD113t-C; HBB

View more View less

UniProt ID: (Human) P68871

View more View less

Entrez Gene ID: (Human) 3043

View more View less

Function(s)

peroxidase activity oxygen transporter activity iron ion binding protein binding oxygen binding heme binding hemoglobin binding haptoglobin binding

Process(es)

receptor-mediated endocytosis blood coagulation regulation of blood pressure positive regulation of cell death oxygen transport bicarbonate transport nitric oxide transport response to hydrogen peroxide hydrogen peroxide catabolic process positive regulation of nitric oxide biosynthetic process regulation of blood vessel size protein heterooligomerization renal absorption platelet aggregation cellular oxidant detoxification

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

HBB Polyclonal Antibody

HBB Antibody (16216-1-AP) in IHC (P)

Product Details

16216-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!