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Invitrogen
HBEGF Polyclonal Antibody
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Product Details
PA5-109805
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human HB-EGF (NP_0019361)
Conjugate
Form
Liquid
Concentration
2.46 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2855216
Product Specific Information
Immunogen sequence: LVTGESLERL RRGLAAGTSN PDPPTVSTDQ LLPLGGGRDR KVRDLQEADL DLLRVTLSSK PQALATPNKE EHGKRKKKGK GLGKKRDPCL RKYKDFCIHG ECKYVKELRA PSCICHPGYH GERCHGLSLP VENRLYTYDH T
Target Information
HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: diphtheria toxin receptor; Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor); diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); hb egf; heparin binding epidermal growth factor-like growth factor; heparin-binding EGF-like growth factor; heparin-binding epidermal -growth - like growth factor; heparin-binding epidermal -growth factor; heparin-binding epidermal growth factor; Proheparin-binding EGF-like growth factor
Gene Aliases: AW047313; DTR; DTS; DTSF; GFHB; Hb-egf; HBEGF; HEGFL
UniProt ID: (Human) Q99075, (Mouse) Q06186, (Rat) Q06175
Entrez Gene ID: (Human) 1839, (Mouse) 15200, (Rat) 25433
angiogenesis
blastocyst growth
epidermal growth factor receptor signaling pathway
regulation of heart contraction
cell migration
positive regulation of cell growth
positive regulation of cell migration
wound healing, spreading of epidermal cells
positive regulation of smooth muscle cell proliferation
negative regulation of elastin biosynthetic process
positive regulation of keratinocyte migration
positive regulation of protein kinase B signaling
positive regulation of wound healing
nervous system development
positive regulation of cell proliferation
MAPK cascade
signal transduction
muscle organ development
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
cell chemotaxis
regulation of cell motility
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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