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Proteintech
HCFC1 Polyclonal Antibody
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Product Details
19358-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HCFC1 Fusion Protein Ag6798 (1-350 aa encoded by BC063435)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASAVSPAN LPAVLLQPRW KRVVGWSGPV PRPRHGHRAV AIKELIVVFG GGNEGIVDEL HVYNTATNQW FIPAVRGDIP PGCAAYGFVC DGTRLLVFGG MVEYGKYSND LYELQASRWE WKRLKAKTPK NGPPPCPRLG HSFSLVGNKC YLFGGLANDS EDPKNNIPRY LNDLYILELR PGSGVVAWDI PITYGVLPPP RESHTAVVYT EKDNKKSKLV IYGGMSGCRL GDLWTLDIDT LTWNKPSLSG VAPLPRSLHS ATTIGNKMYV FGGWVPLVMD DVKVATHEKE WKCTNTLACL NLDTMAWETI LMDTLEDNIP RARAGHCAVA INTRLYIWSG RDGYRKAWNN Q (1-350 aa encoded by BC063435)
Target Information
Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C1 factor; CFF; HCF; hcfc1; Host cell factor 1; protein phosphatase 1, regulatory subunit 89; VCAF; VP16 accessory protein; VP16-accessory protein
Gene Aliases: AW060991; CFF; HCF; HCF-1; HCF1; HCFC1; HFC1; MRX3; PPP1R89; RGD1563804; VCAF
UniProt ID: (Human) P51610, (Mouse) Q61191
Entrez Gene ID: (Human) 3054, (Rat) 363519, (Mouse) 15161
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
identical protein binding
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K16 specific)
cadherin binding involved in cell-cell adhesion
molecular_function
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of gene expression
release from viral latency
regulation of protein complex assembly
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
positive regulation of transcription from RNA polymerase II promoter
protein stabilization
cellular response to organic cyclic compound
mitochondrion organization
cell cycle
positive regulation of cell cycle
cell-cell adhesion
chromatin modification
regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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