Invitrogen

HCK Polyclonal Antibody

View all (21) HCK antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-102573

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HCK(Accession P08631), corresponding to amino acid residues N496-P526.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2851975

Product Specific Information

Antibody detects endogenous levels of total Hck.

Target Information

Hematopoietic cell kinase (HCK) is a SRC-related kinase expressed in lymphoid and hematopoietic cells and may play a role in some forms of leukemia. (HCK Alias: DKFZp686D0638). HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: B cell/myeloid kinase; B-cell/myeloid kinase; BMK; Hematopoietic cell kinase; Hemopoietic cell kinase; hemopoietic cell tyrosine kinase; p56-HCK; p56-HCK/p59-HCK; p56Hck; p59-HCK/p60-HCK; p59Hck; p61Hck; Tyrosine-protein kinase HCK

View more View less

Gene Aliases: AI849071; Bmk; HCK; Hctk; JTK9; p56Hck; p59Hck; p61Hck

View more View less

UniProt ID: (Human) P08631, (Rat) P50545, (Mouse) P08103

View more View less

Entrez Gene ID: (Human) 3055, (Rat) 25734, (Mouse) 15162

View more View less

Function(s)
protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
exocytosis phagocytosis inflammatory response cytoskeleton organization transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of cell shape peptidyl-tyrosine phosphorylation cell differentiation peptidyl-tyrosine autophosphorylation regulation of cell proliferation negative regulation of apoptotic process innate immune response protein autophosphorylation regulation of phagocytosis defense response to Gram-positive bacterium regulation of sequence-specific DNA binding transcription factor activity cellular response to peptide hormone stimulus regulation of podosome assembly positive regulation of actin cytoskeleton reorganization leukocyte migration involved in immune response innate immune response-activating signal transduction protein phosphorylation cell adhesion integrin-mediated signaling pathway mesoderm development viral process cytokine-mediated signaling pathway positive regulation of actin filament polymerization lipopolysaccharide-mediated signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis leukocyte degranulation respiratory burst after phagocytosis regulation of defense response to virus by virus regulation of inflammatory response interferon-gamma-mediated signaling pathway immune system process phosphorylation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support