Invitrogen

HCK Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-105729

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HCK(Accession P08631), corresponding to amino acid residues N496-P526.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2853912

Product Specific Information

Antibody detects endogenous levels of total Hck.

Target Information

Hematopoietic cell kinase (HCK) is a SRC-related kinase expressed in lymphoid and hematopoietic cells and may play a role in some forms of leukemia. (HCK Alias: DKFZp686D0638). HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell/myeloid kinase; B-cell/myeloid kinase; BMK; Hematopoietic cell kinase; Hemopoietic cell kinase; p56-HCK/p59-HCK; p59-HCK/p60-HCK; p59Hck; p61Hck; Tyrosine-protein kinase HCK

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Gene Aliases: AI849071; Bmk; HCK; JTK9; p59Hck; p61Hck

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UniProt ID: (Human) P08631, (Mouse) P08103

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Entrez Gene ID: (Human) 3055, (Mouse) 15162

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Function(s)
protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
leukocyte migration involved in immune response innate immune response-activating signal transduction protein phosphorylation inflammatory response cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway integrin-mediated signaling pathway mesoderm development positive regulation of cell proliferation regulation of cell shape viral process peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cell differentiation positive regulation of actin filament polymerization lipopolysaccharide-mediated signaling pathway peptidyl-tyrosine autophosphorylation Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of apoptotic process leukocyte degranulation respiratory burst after phagocytosis protein autophosphorylation regulation of defense response to virus by virus regulation of inflammatory response regulation of phagocytosis regulation of sequence-specific DNA binding transcription factor activity interferon-gamma-mediated signaling pathway regulation of podosome assembly positive regulation of actin cytoskeleton reorganization immune system process exocytosis phagocytosis phosphorylation regulation of cell proliferation innate immune response defense response to Gram-positive bacterium cellular response to peptide hormone stimulus
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