Invitrogen

HCK Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-89892

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 324-505 of human HCK (NP_0011656001)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.55 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805826

Product Specific Information

Immunogen sequence: LKSDEGSKQP LPKLIDFSAQ IAEGMAFIEQ RNYIHRDLRA ANILVSASLV CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGSF TIKSDVWSFG ILLMEIVTYG RIPYPGMSNP EVIRALERGY RMPRPENCPE ELYNIMMRCW KNRPEERPTF EYIQSVLDDF YTATESQYQQ QP; Positive Samples: Raji, Mouse spleen, Mouse lung, Rat spleen; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Lipid-anchor, Lysosome, Membrane, Nucleus, caveola, cytoskeleton, cytosol, cytosol, focal adhesion, podosome membrane, secretory vesicle

Target Information

Hematopoietic cell kinase (HCK) is a SRC-related kinase expressed in lymphoid and hematopoietic cells and may play a role in some forms of leukemia. (HCK Alias: DKFZp686D0638). HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell/myeloid kinase; B-cell/myeloid kinase; BMK; Hematopoietic cell kinase; Hemopoietic cell kinase; hemopoietic cell tyrosine kinase; p56-HCK; p56-HCK/p59-HCK; p56Hck; p59-HCK/p60-HCK; p59Hck; p61Hck; Tyrosine-protein kinase HCK

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Gene Aliases: AI849071; Bmk; HCK; Hctk; JTK9; p56Hck; p59Hck; p61Hck

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UniProt ID: (Human) P08631, (Rat) P50545, (Mouse) P08103

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Entrez Gene ID: (Human) 3055, (Rat) 25734, (Mouse) 15162

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Function(s)
protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
exocytosis phagocytosis inflammatory response cytoskeleton organization transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of cell shape peptidyl-tyrosine phosphorylation cell differentiation peptidyl-tyrosine autophosphorylation regulation of cell proliferation negative regulation of apoptotic process innate immune response protein autophosphorylation regulation of phagocytosis defense response to Gram-positive bacterium regulation of sequence-specific DNA binding transcription factor activity cellular response to peptide hormone stimulus regulation of podosome assembly positive regulation of actin cytoskeleton reorganization leukocyte migration involved in immune response innate immune response-activating signal transduction protein phosphorylation cell adhesion integrin-mediated signaling pathway mesoderm development viral process cytokine-mediated signaling pathway positive regulation of actin filament polymerization lipopolysaccharide-mediated signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis leukocyte degranulation respiratory burst after phagocytosis regulation of defense response to virus by virus regulation of inflammatory response interferon-gamma-mediated signaling pathway immune system process phosphorylation
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