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Invitrogen
HCLS1 Recombinant Rabbit Monoclonal Antibody (PSH01-12)
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FIGURE: 1 / 10
HCLS1 Antibody (MA5-49608) in ICC/IF
Immunofluorescence analysis of HCLS1 was performed using 70% confluent log phase Raji and HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with HCLS1 Rabbit Recombinant Monoclonal Antibody (PSH01-12) (Product # MA5-49608 ) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, ... View More
Product Details
MA5-49608
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH01-12
Immunogen
Recombinant protein within human hcls1 aa 201-450/486
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3092879
Product Specific Information
Sequence Similarities: 70% Mouse.
Tissue Specificity: Expressed only in tissues and cells of hematopoietic origin. Expressed in early stage of myeloid and erythroid differentiation.
Positive Control: Ramos cell lysate, Daudi cell lysate, Raji cell lysate, Jurkat cell lysate, HL-60 cell lysate, human lung carcinoma tissue, human liver tissue, HL-60, Jurkat.
Subcellular Location: Membrane, Cytoplasm, Mitochondrion.
Predicted band size: 54 kDa.
Target Information
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hematopoietic cell-specific LYN substrate 1; Hematopoietic lineage cell-specific protein; LckBP1; p75
Gene Aliases: CTTNL; HCLS1; HS1; lckBP1; p75
UniProt ID: (Human) P14317
Entrez Gene ID: (Human) 3059
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
positive regulation of cell proliferation
response to hormone
positive regulation of phosphatidylinositol 3-kinase signaling
actin filament polymerization
erythrocyte differentiation
regulation of actin filament polymerization
positive regulation of granulocyte differentiation
positive regulation of peptidyl-serine phosphorylation
intracellular signal transduction
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of transcription factor import into nucleus
positive regulation of macrophage differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein kinase B signaling
cellular response to cytokine stimulus
negative regulation of leukocyte apoptotic process
positive regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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