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Invitrogen
HCN3 Monoclonal Antibody (TLL6C5)
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HCN3 Antibody (MA3-902) in IHC (P)
Immunohistochemistry was performed on cancer biopsies of deparaffinized Human colon carcinoma tissues. To expose target proteins, heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes. Following antigen retrieval tissues were blocked in 3% BSA-PBS for 30 minutes at room temperature. Tissues were then probed at a dilution of 1:20 with a rat monoclo... View More
Product Details
MA3-902
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
TLL6C5
Immunogen
Synthetic peptide corresponding to residues T(640) L L A R S A R R S A G S P A S P L V P V R A G P L L A R G P W A S T S(675) of rat HCN3.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2115028
Product Specific Information
MA3-902 detects HCN3 from human, mouse and rat samples.
MA3-902 has been successfully used in Western blotting and immunohistochemistry procedures. By Western blot MA3-902 detects a ~90 KDa band representing HCN3.
The MA3-902 immunogen is a synthetic peptide corresponding to residues T(640) L L A R S A R R S A G S P A S P L V P V R A G P L L A R G P W A S T S(675) of rat HCN3.
MA3-902 (clone TLL6C5) is a rat monoclonal hybridoma, produced by immunizing a rat, isolating the spleen cells, creating the hybridoma and successively injecting these cells into a mouse to produce ascites.
Target Information
HCN3 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. HCN3 has been detected in the brain, but with less expression than other HCN channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HAC-3; hyperpolarization activated cyclic nucleotide-gated potassium channel 3; Hyperpolarization-activated cation channel 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4; MGC131493; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Gene Aliases: BCNG-4; Bcng4; Hac3; HCN3; Hcn4; KIAA1535
UniProt ID: (Human) Q9P1Z3, (Mouse) O88705, (Rat) Q9JKA8
Entrez Gene ID: (Human) 57657, (Mouse) 15168, (Rat) 114245
transport
ion transport
potassium ion transport
sodium ion transport
regulation of ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
transmembrane transport
potassium ion transmembrane transport
regulation of postsynaptic membrane potential
cellular response to cAMP
response to cisplatin
cellular response to dopamine
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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