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Product Details
H00010021-M04
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2A5
Immunogen
HCN4 (NP_005468.1, 1105 a.a. approximately 1203 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: SPHSSGESMA AFPLFPRAGG GSGGSGSSGG LGPPGRPYGA IPGQHVTLPR KTSSGSLPPP LSLFGARATS SGGPPLTAGP QREPGARPEP VRSKLPSNL
Target Information
HCN4 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene Aliases: HCN4; SSS2
UniProt ID: (Human) Q9Y3Q4
Entrez Gene ID: (Human) 10021
regulation of heart rate
regulation of membrane depolarization
cation transport
muscle contraction
blood circulation
regulation of ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
regulation of cardiac muscle contraction
regulation of postsynaptic membrane potential
cellular response to cAMP
cellular response to cGMP
potassium ion transmembrane transport
SA node cell action potential
regulation of heart rate by cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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