Proteintech

HDAC5 Polyclonal Antibody

HDAC5 Antibody in Immunocytochemistry (ICC/IF)

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HDAC5 Antibody (16166-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed HeLa cells using 16166-1-AP (HDAC5-specific antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

HDAC5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

16166-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Immunoprecipitation (IP)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody only binds HDAC5. It does not cross-react with other HDACs.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta.

Journal of orthopaedic translation

Sun B,Wu H,Lu J,Zhang R,Shen X,Gu Y,Shi C,Zhang Y,Yuan W

Sun Jan 01 00:00:00 UTC 2023

HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.

Cancer letters

Sun X,Zhang K,Peng X,Zhou P,Qu C,Yang L,Shen L

Sun May 28 00:00:00 UTC 2023

Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury.

Frontiers in medicine

He X,Sun T,Zhang P,Xia Z,Gao C,Ren H,Ji D

Sat Jul 16 00:00:00 UTC 2022

Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury.

Frontiers in medicine

He X,Sun T,Zhang P,Xia Z,Gao C,Ren H,Ji D

Sat Jul 16 00:00:00 UTC 2022

WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.

Cell death & disease

Feng Y,Ma Z,Pan M,Xu L,Feng J,Zhang Y,Shao C,Guo K,Duan H,Zhang Y,Zhang Y,Zhang J,Lu D,Ren X,Han J,Li X,Yan X

Fri May 20 00:00:00 UTC 2022

microRNA-671-5p reduces tumorigenicity of ovarian cancer via suppressing HDAC5 and HIF-1α expression.

Chemico-biological interactions

Peng D,Wu T,Wang J,Huang J,Zheng L,Wang P,Li J,Wu L,Luo M

Tue Mar 01 00:00:00 UTC 2022

microRNA-671-5p reduces tumorigenicity of ovarian cancer via suppressing HDAC5 and HIF-1α expression.

Chemico-biological interactions

Peng D,Wu T,Wang J,Huang J,Zheng L,Wang P,Li J,Wu L,Luo M

Tue Mar 01 00:00:00 UTC 2022

HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome.

Folia histochemica et cytobiologica

Wang Y,Wang Y,Chen Y,Gao Q,Hou L,Feng X

Mon Oct 03 00:00:00 UTC 2022

HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome.

Folia histochemica et cytobiologica

Wang Y,Wang Y,Chen Y,Gao Q,Hou L,Feng X

Mon Oct 03 00:00:00 UTC 2022

EGCG prevents pressure overload‑induced myocardial remodeling by downregulating overexpression of HDAC5 in mice.

International journal of molecular medicine

Han X,Peng C,Huang L,Luo X,Mao Q,Wu S,Zhang H

Sat Jan 01 00:00:00 UTC 2022

EGCG prevents pressure overload‑induced myocardial remodeling by downregulating overexpression of HDAC5 in mice.

International journal of molecular medicine

Han X,Peng C,Huang L,Luo X,Mao Q,Wu S,Zhang H

Sat Jan 01 00:00:00 UTC 2022

ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer.

Cancer letters

Zhou C,Li S,Bin K,Qin G,Pan P,Ren D,Zhao Y,Xia W,Chen J,Liu J,Wu H,Zhou Y

Fri Oct 28 00:00:00 UTC 2022

Development of a cancer cells self‑activating and miR‑125a‑5p expressing poly‑pharmacological nanodrug for cancer treatment.

International journal of molecular medicine

Chang YC,Shieh MC,Chang YH,Huang WL,Su WC,Cheng FY,Cheung CHA

Mon Aug 01 00:00:00 UTC 2022

Trichostatin A increases BDNF protein expression by improving XBP-1s/ATF6/GRP78 axis in Schwann cells of diabetic peripheral neuropathy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

An J,Zhang X,Jia K,Zhang C,Zhu L,Cheng M,Li F,Zhao S,Hao J

Fri Jan 01 00:00:00 UTC 2021

Trichostatin A increases BDNF protein expression by improving XBP-1s/ATF6/GRP78 axis in Schwann cells of diabetic peripheral neuropathy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

An J,Zhang X,Jia K,Zhang C,Zhu L,Cheng M,Li F,Zhao S,Hao J

Fri Jan 01 00:00:00 UTC 2021

Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.

Journal of cellular and molecular medicine

Feng S,Zhang L,Liu X,Li G,Zhang B,Wang Z,Zhang H,Ma H

Wed Jul 01 00:00:00 UTC 2020

Repeated stress exposure in mid-adolescence attenuates behavioral, noradrenergic, and epigenetic effects of trauma-like stress in early adult male rats.

Scientific reports

Chaby LE,Sadik N,Burson NA,Lloyd S,O'Donnel K,Winters J,Conti AC,Liberzon I,Perrine SA

Wed Oct 21 00:00:00 UTC 2020

STAT3 phosphorylation mediates high glucose-impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Du W,Wang N,Li F,Jia K,An J,Liu Y,Wang Y,Zhu L,Zhao S,Hao J

Mon Jul 01 00:00:00 UTC 2019

STAT3 phosphorylation mediates high glucose-impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Du W,Wang N,Li F,Jia K,An J,Liu Y,Wang Y,Zhu L,Zhao S,Hao J

Mon Jul 01 00:00:00 UTC 2019

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Cell

Huang X,Yan J,Zhang M,Wang Y,Chen Y,Fu X,Wei R,Zheng XL,Liu Z,Zhang X,Yang H,Hao B,Shen YY,Su Y,Cong X,Huang M,Tan M,Ding J,Geng M

Thu Sep 20 00:00:00 UTC 2018

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Cell

Huang X,Yan J,Zhang M,Wang Y,Chen Y,Fu X,Wei R,Zheng XL,Liu Z,Zhang X,Yang H,Hao B,Shen YY,Su Y,Cong X,Huang M,Tan M,Ding J,Geng M

Thu Sep 20 00:00:00 UTC 2018

HDAC2 and HDAC5 Up-Regulations Modulate Survivin and miR-125a-5p Expressions and Promote Hormone Therapy Resistance in Estrogen Receptor Positive Breast Cancer Cells.

Frontiers in pharmacology

Huang WT,Tsai YH,Chen SH,Kuo CW,Kuo YL,Lee KT,Chen WC,Wu PC,Chuang CY,Cheng SM,Lin CH,Leung EY,Chang YC,Cheung CHA

Wed Sep 30 00:00:00 UTC 2020

Antithetical regulation of α-myosin heavy chain between fetal and adult heart failure though shuttling of HDAC5 regulating YY-1 function.

Cardiovascular toxicology

Fang J,Li Y,Zhou K,Hua Y,Wang C,Mu D

Wed Apr 01 00:00:00 UTC 2015

Antithetical regulation of α-myosin heavy chain between fetal and adult heart failure though shuttling of HDAC5 regulating YY-1 function.

Cardiovascular toxicology

Fang J,Li Y,Zhou K,Hua Y,Wang C,Mu D

Wed Apr 01 00:00:00 UTC 2015

Antithetical regulation of α-myosin heavy chain between fetal and adult heart failure though shuttling of HDAC5 regulating YY-1 function.

Cardiovascular toxicology

Fang J,Li Y,Zhou K,Hua Y,Wang C,Mu D

Wed Apr 01 00:00:00 UTC 2015

Antithetical regulation of α-myosin heavy chain between fetal and adult heart failure though shuttling of HDAC5 regulating YY-1 function.

Cardiovascular toxicology

Fang J,Li Y,Zhou K,Hua Y,Wang C,Mu D

Wed Apr 01 00:00:00 UTC 2015

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international