Proteintech

HDAC6 Polyclonal Antibody

HDAC6 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

HDAC6 Antibody (12834-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 12834-1-AP (HDAC6 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

HDAC6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HDAC6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12834-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 39 publications 39 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 5 publications 5 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HDAC6 Fusion Protein Ag3572 (712-1064 aa encoded by BC013737)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against residues near the C terminal of human HDAC6.

Immunogen sequence: AERMTTREK KVLEAGMGKV TSASFGEEST PGQTNSETAV VALTQDQPSE AATGGATLAQ TISEAAIGGA MLGQTTSEEA VGGATPDQTT SEETVGGAIL DQTTSEDAVG GATLGQTTSE EAVGGATLAQ TTSEAAMEGA TLDQTTSEEA PGGTELIQTP LASSTDHQTP PTSPVQGTTP QISPSTLIGS LRTLELGSES QGASESQAPG EENLLGEAAG GQDMADSMLM QGSRGLTDQA IFYAVTPLPW CPHLVAVCPI PAAGLDVTQP CGDCGTIQEN WVCLSCYQVY CGRYINGHML QHHGNSGHPL VLSYIDLSAW CYYCQAYVHH QALLDVKNIA HQNKFGEDMP HPH (712-1064 aa encoded by B C013737)

Target Information

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration.

Cell reports

Szewczyk B,Günther R,Japtok J,Frech MJ,Naumann M,Lee HO,Hermann A

Tue Feb 28 00:00:00 UTC 2023

HDAC6 Triggers the ATM-Dependent DNA Damage Response To Promote PRV Replication.

Microbiology spectrum

Xu W,Yan P,Zhou Z,Yao J,Pan H,Jiang L,Bo Z,Ni B,Sun M,Gao S,Huan C

Thu Mar 23 00:00:00 UTC 2023

HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.

Oncogene

Liu B,Zhang J,Meng X,Xie SM,Liu F,Chen H,Yao D,Li M,Guo M,Shen H,Zhang X,Xing L

Sat Apr 01 00:00:00 UTC 2023

HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.

Oncogene

Liu B,Zhang J,Meng X,Xie SM,Liu F,Chen H,Yao D,Li M,Guo M,Shen H,Zhang X,Xing L

Sat Apr 01 00:00:00 UTC 2023

LIPUS accelerates bone regeneration via HDAC6-mediated ciliogenesis.

Biochemical and biophysical research communications

Xiao H,Yan A,Li M,Wang L,Xiang J

Sun Jan 22 00:00:00 UTC 2023

LIPUS accelerates bone regeneration via HDAC6-mediated ciliogenesis.

Biochemical and biophysical research communications

Xiao H,Yan A,Li M,Wang L,Xiang J

Sun Jan 22 00:00:00 UTC 2023

HDAC6 Inhibition Alleviates Anesthesia and Surgery-Induced Less Medial Prefrontal-Dorsal Hippocampus Connectivity and Cognitive Impairment in Aged Rats.

Molecular neurobiology

Chen J,Liu S,Wang X,Huang J,Phillips J,Ma D,Ouyang W,Tong J

Sat Oct 01 00:00:00 UTC 2022

Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer.

Cell death & disease

Zhang D,Tang J,Xu Y,Huang X,Wang Y,Jin X,Wu G,Liu P

Wed Aug 17 00:00:00 UTC 2022

Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis.

Cellular and molecular life sciences : CMLS

Zou YJ,Shan MM,Wan X,Liu JC,Zhang KH,Ju JQ,Xing CH,Sun SC

Thu Jul 14 00:00:00 UTC 2022

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.

Genome biology

Yuan S,Huang T,Bao Z,Wang S,Wu X,Liu J,Liu H,Chen ZJ

Tue Sep 06 00:00:00 UTC 2022

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.

Genome biology

Yuan S,Huang T,Bao Z,Wang S,Wu X,Liu J,Liu H,Chen ZJ

Tue Sep 06 00:00:00 UTC 2022

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.

Genome biology

Yuan S,Huang T,Bao Z,Wang S,Wu X,Liu J,Liu H,Chen ZJ

Tue Sep 06 00:00:00 UTC 2022

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.

Genome biology

Yuan S,Huang T,Bao Z,Wang S,Wu X,Liu J,Liu H,Chen ZJ

Tue Sep 06 00:00:00 UTC 2022

WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.

Cell death & disease

Feng Y,Ma Z,Pan M,Xu L,Feng J,Zhang Y,Shao C,Guo K,Duan H,Zhang Y,Zhang Y,Zhang J,Lu D,Ren X,Han J,Li X,Yan X

Fri May 20 00:00:00 UTC 2022

CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells.

Cell regeneration (London, England)

Gong S,Hu G,Guo R,Zhang J,Yang Y,Ji B,Li G,Yao H

Mon Sep 19 00:00:00 UTC 2022

PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhang C,Tang Q,Xia H,Xu H,Bi F

Sat Jan 01 00:00:00 UTC 2022

Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis.

Development (Cambridge, England)

Shan MM,Zou YJ,Pan ZN,Zhang HL,Xu Y,Ju JQ,Sun SC

Tue Mar 01 00:00:00 UTC 2022

Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.

Journal of the American Heart Association

Xu J,Zhao X,Jiang X,He L,Wu X,Wang J,Chen Q,Li Y,Zhang M

Tue Apr 05 00:00:00 UTC 2022

Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer's disease.

Frontiers in cell and developmental biology

Martínez-Hernández J,Parato J,Sharma A,Soleilhac JM,Qu X,Tein E,Sproul A,Andrieux A,Goldberg Y,Moutin MJ,Bartolini F,Peris L

Wed Sep 28 00:00:00 UTC 2022

Targeting the lncMST-EPRS/HSP90AB1 complex as novel therapeutic strategy for T-2 toxin-induced growth retardation.

Ecotoxicology and environmental safety

Lu Q,Guo P,Li H,Liu Y,Yuan L,Zhang B,Wu Q,Wang X

Thu Dec 01 00:00:00 UTC 2022

Targeting the lncMST-EPRS/HSP90AB1 complex as novel therapeutic strategy for T-2 toxin-induced growth retardation.

Ecotoxicology and environmental safety

Lu Q,Guo P,Li H,Liu Y,Yuan L,Zhang B,Wu Q,Wang X

Thu Dec 01 00:00:00 UTC 2022

Inhibition of Ciliogenesis Enhances the Cellular Sensitivity to Temozolomide and Ionizing Radiation in Human Glioblastoma Cells.

Biomedical and environmental sciences : BES

Wei L,Ma W,Cai H,Peng SP,Tian HB,Wang JF,Gao L,He JP

Fri May 20 00:00:00 UTC 2022

S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.

Cellular and molecular gastroenterology and hepatology

Zhang L,Zhang Z,Li C,Zhu T,Gao J,Zhou H,Zheng Y,Chang Q,Wang M,Wu J,Ran L,Wu Y,Miao H,Zou X,Liang B

Mon Dec 20 00:00:00 UTC 2021

S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.

Cellular and molecular gastroenterology and hepatology

Zhang L,Zhang Z,Li C,Zhu T,Gao J,Zhou H,Zheng Y,Chang Q,Wang M,Wu J,Ran L,Wu Y,Miao H,Zou X,Liang B

Mon Dec 20 00:00:00 UTC 2021

S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.

Cellular and molecular gastroenterology and hepatology

Zhang L,Zhang Z,Li C,Zhu T,Gao J,Zhou H,Zheng Y,Chang Q,Wang M,Wu J,Ran L,Wu Y,Miao H,Zou X,Liang B

Mon Dec 20 00:00:00 UTC 2021

Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.

Frontiers in oncology

Yan X,Qu X,Liu B,Zhao Y,Xu L,Yu S,Wang J,Wang L,Su J

Tue Dec 07 00:00:00 UTC 2021

Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.

eLife

Gopalan J,Omar MH,Roy A,Cruz NM,Falcone J,Jones KN,Forbush KA,Himmelfarb J,Freedman BS,Scott JD

Mon Jul 12 00:00:00 UTC 2021

LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing VEGF Gene Transcription via Enhancing H3K9 Deacetylation by Recruiting HDAC6.

Frontiers in cell and developmental biology

Kai H,Wu Q,Yin R,Tang X,Shi H,Wang T,Zhang M,Pan C

Tue Jul 27 00:00:00 UTC 2021

LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing VEGF Gene Transcription via Enhancing H3K9 Deacetylation by Recruiting HDAC6.

Frontiers in cell and developmental biology

Kai H,Wu Q,Yin R,Tang X,Shi H,Wang T,Zhang M,Pan C

Tue Jul 27 00:00:00 UTC 2021

LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing VEGF Gene Transcription via Enhancing H3K9 Deacetylation by Recruiting HDAC6.

Frontiers in cell and developmental biology

Kai H,Wu Q,Yin R,Tang X,Shi H,Wang T,Zhang M,Pan C

Tue Jul 27 00:00:00 UTC 2021

HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation.

Frontiers in cell and developmental biology

Zhan Y,Wang H,Zhang L,Pei F,Chen Z

Fri Dec 18 00:00:00 UTC 2020

HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation.

Frontiers in cell and developmental biology

Zhan Y,Wang H,Zhang L,Pei F,Chen Z

Fri Dec 18 00:00:00 UTC 2020

Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage.

Molecular human reproduction

Yao Y,Hao F,Tang LC,Xu XH,Jin L

Wed Jul 01 00:00:00 UTC 2020

Inhibition of Histone Deacetylase 6 by Tubastatin A Attenuates the Progress of Osteoarthritis via Improving Mitochondrial Function.

The American journal of pathology

Zheng Y,Chen Y,Lu X,Weng Q,Dai G,Yu Y,Yu K,Gao W

Tue Dec 01 00:00:00 UTC 2020

Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.

Experimental neurology

Zheng Z,Zhou Y,Ye L,Lu Q,Zhang K,Zhang J,Xie L,Wu Y,Xu K,Zhang H,Xiao J

Sat Feb 01 00:00:00 UTC 2020

Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.

Experimental neurology

Zheng Z,Zhou Y,Ye L,Lu Q,Zhang K,Zhang J,Xie L,Wu Y,Xu K,Zhang H,Xiao J

Sat Feb 01 00:00:00 UTC 2020

Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules.

Biochimica et biophysica acta. Molecular cell research

Tang K,Li S,Li P,Xia Q,Yang R,Li T,Li L,Jiang Y,Qin X,Yang H,Wu C,You F,Tan Y,Liu Y

Fri May 01 00:00:00 UTC 2020

HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.

Frontiers in microbiology

Zheng Y,Zhu G,Tang Y,Yan J,Han S,Yin J,Peng B,He X,Liu W

Mon Sep 28 00:00:00 UTC 2020

Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway.

The Journal of thoracic and cardiovascular surgery

Fu Z,Li F,Jia L,Su S,Wang Y,Cai Z,Xiang M

Thu Aug 01 00:00:00 UTC 2019

Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway.

The Journal of thoracic and cardiovascular surgery

Fu Z,Li F,Jia L,Su S,Wang Y,Cai Z,Xiang M

Thu Aug 01 00:00:00 UTC 2019

Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway.

The Journal of thoracic and cardiovascular surgery

Fu Z,Li F,Jia L,Su S,Wang Y,Cai Z,Xiang M

Thu Aug 01 00:00:00 UTC 2019

Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway.

The Journal of thoracic and cardiovascular surgery

Fu Z,Li F,Jia L,Su S,Wang Y,Cai Z,Xiang M

Thu Aug 01 00:00:00 UTC 2019

Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.

Development (Cambridge, England)

Wang HH,Zhang Y,Tang F,Pan MH,Wan X,Li XH,Sun SC

Mon Feb 04 00:00:00 UTC 2019

Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics.

Cell reports

Markmiller S,Fulzele A,Higgins R,Leonard M,Yeo GW,Bennett EJ

Tue Apr 30 00:00:00 UTC 2019

Histone deacetylases and acetylated histone H3 are involved in the process of hepatitis B virus DNA replication.

Life sciences

Zhang D,Wang Y,Zhang HY,Jiao FZ,Zhang WB,Wang LW,Zhang H,Gong ZJ

Mon Apr 15 00:00:00 UTC 2019

Histone deacetylases and acetylated histone H3 are involved in the process of hepatitis B virus DNA replication.

Life sciences

Zhang D,Wang Y,Zhang HY,Jiao FZ,Zhang WB,Wang LW,Zhang H,Gong ZJ

Mon Apr 15 00:00:00 UTC 2019

Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.

Cancer research

Wang D,Li W,Zhao R,Chen L,Liu N,Tian Y,Zhao H,Xie M,Lu F,Fang Q,Liang W,Yin F,Li Z

Mon Apr 15 00:00:00 UTC 2019

Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle-Mediated Lysosome-Autophagy System.

Small (Weinheim an der Bergstrasse, Germany)

Liu J,Kang Y,Yin S,Chen A,Wu J,Liang H,Shao L

Sat Jun 01 00:00:00 UTC 2019

RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.

Molecular human reproduction

Zhang Y,Wan X,Wang HH,Pan MH,Pan ZN,Sun SC

Mon Jul 01 00:00:00 UTC 2019

hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells.

International journal of oncology

Li Z,Liu X,Ma J,Zhang T,Gao X,Liu L

Thu Nov 01 00:00:00 UTC 2018

An Interaction Landscape of Ubiquitin Signaling.

Molecular cell

Zhang X,Smits AH,van Tilburg GB,Jansen PW,Makowski MM,Ovaa H,Vermeulen M

Thu Mar 02 00:00:00 UTC 2017

An Interaction Landscape of Ubiquitin Signaling.

Molecular cell

Zhang X,Smits AH,van Tilburg GB,Jansen PW,Makowski MM,Ovaa H,Vermeulen M

Thu Mar 02 00:00:00 UTC 2017

Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.

British journal of cancer

Liang X,Shi H,Yang L,Qiu C,Lin S,Qi Y,Li J,Zhao A,Liu J

Tue Mar 28 00:00:00 UTC 2017

Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.

British journal of cancer

Liang X,Shi H,Yang L,Qiu C,Lin S,Qi Y,Li J,Zhao A,Liu J

Tue Mar 28 00:00:00 UTC 2017

Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.

Frontiers in molecular neuroscience

Wobst HJ,Wesolowski SS,Chadchankar J,Delsing L,Jacobsen S,Mukherjee J,Deeb TZ,Dunlop J,Brandon NJ,Moss SJ

Tue Nov 15 00:00:00 UTC 2022

Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.

Frontiers in molecular neuroscience

Wobst HJ,Wesolowski SS,Chadchankar J,Delsing L,Jacobsen S,Mukherjee J,Deeb TZ,Dunlop J,Brandon NJ,Moss SJ

Tue Nov 15 00:00:00 UTC 2022

Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging.

Journal of periodontology

Li Q,Ma Y,Zhu Y,Zhang T,Zhou Y

Sun Jan 01 00:00:00 UTC 2017

Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging.

Journal of periodontology

Li Q,Ma Y,Zhu Y,Zhang T,Zhou Y

Sun Jan 01 00:00:00 UTC 2017

Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.

Neuroscience letters

Jian W,Wei X,Chen L,Wang Z,Sun Y,Zhu S,Lou H,Yan S,Li X,Zhou J,Zhang B

Fri Sep 29 00:00:00 UTC 2017

Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.

Neuroscience letters

Jian W,Wei X,Chen L,Wang Z,Sun Y,Zhu S,Lou H,Yan S,Li X,Zhou J,Zhang B

Fri Sep 29 00:00:00 UTC 2017

Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.

Neuroscience letters

Jian W,Wei X,Chen L,Wang Z,Sun Y,Zhu S,Lou H,Yan S,Li X,Zhou J,Zhang B

Fri Sep 29 00:00:00 UTC 2017

Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.

Neuroscience letters

Jian W,Wei X,Chen L,Wang Z,Sun Y,Zhu S,Lou H,Yan S,Li X,Zhou J,Zhang B

Fri Sep 29 00:00:00 UTC 2017

HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.

Oncology reports

Wang Z,Tang F,Hu P,Wang Y,Gong J,Sun S,Xie C

Fri Jul 01 00:00:00 UTC 2016

HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.

Oncology reports

Wang Z,Tang F,Hu P,Wang Y,Gong J,Sun S,Xie C

Fri Jul 01 00:00:00 UTC 2016

Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.

Oncology reports

Cai M,Hu Z,Liu J,Gao J,Tan M,Zhang D,Zhu L,Liu S,Hou R,Lin B

Sun Feb 01 00:00:00 UTC 2015

Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.

International journal of oncology

Zhu L,Yang J,Zhao L,Yu X,Wang L,Wang F,Cai Y,Jin J

Tue Jan 26 00:00:00 UTC 2016

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international

Wang X,Liu J,Zhen J,Zhang C,Wan Q,Liu G,Wei X,Zhang Y,Wang Z,Han H,Xu H,Bao C,Song Z,Zhang X,Li N,Yi F

Wed Oct 01 00:00:00 UTC 2014

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international

Wang X,Liu J,Zhen J,Zhang C,Wan Q,Liu G,Wei X,Zhang Y,Wang Z,Han H,Xu H,Bao C,Song Z,Zhang X,Li N,Yi F

Wed Oct 01 00:00:00 UTC 2014

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international

Wang X,Liu J,Zhen J,Zhang C,Wan Q,Liu G,Wei X,Zhang Y,Wang Z,Han H,Xu H,Bao C,Song Z,Zhang X,Li N,Yi F

Wed Oct 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: FLJ16239; HD6; HDA6; Histone deacetylase 6; Protein deacetylase HDAC6; protein phosphatase 1, regulatory subunit 90; Tubulin-lysine deacetylase HDAC6

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Gene Aliases: CPBHM; HD6; HDAC6; JM21; KIAA0901; PPP1R90

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UniProt ID: (Human) Q9UBN7

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Entrez Gene ID: (Human) 10013

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Function(s)

core promoter binding actin binding histone deacetylase activity protein binding beta-catenin binding microtubule binding zinc ion binding enzyme binding polyubiquitin binding ubiquitin protein ligase binding NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase binding tubulin deacetylase activity alpha-tubulin binding tau protein binding beta-tubulin binding misfolded protein binding Hsp90 protein binding dynein complex binding

Process(es)

protein polyubiquitination transcription, DNA-templated protein deacetylation misfolded or incompletely synthesized protein catabolic process intracellular protein transport organelle organization negative regulation of microtubule depolymerization response to toxic substance positive regulation of signal transduction response to organic substance regulation of receptor activity regulation of autophagy positive regulation of epithelial cell migration negative regulation of hydrogen peroxide metabolic process positive regulation of receptor biosynthetic process macroautophagy histone deacetylation regulation of protein stability lysosome localization peptidyl-lysine deacetylation cellular response to topologically incorrect protein regulation of gene expression, epigenetic ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein complex disassembly negative regulation of protein complex disassembly regulation of fat cell differentiation negative regulation of proteolysis negative regulation of transcription, DNA-templated negative regulation of oxidoreductase activity mitochondrion localization response to misfolded protein regulation of microtubule-based movement regulation of androgen receptor signaling pathway regulation of establishment of protein localization cellular response to hydrogen peroxide aggresome assembly polyubiquitinated misfolded protein transport Hsp90 deacetylation response to growth factor histone H3 deacetylation cellular response to misfolded protein positive regulation of chaperone-mediated protein complex assembly tubulin deacetylation mitophagy in response to mitochondrial depolarization positive regulation of hydrogen peroxide-mediated programmed cell death regulation of mitophagy

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HDAC6 Polyclonal Antibody

HDAC6 Antibody (12834-1-AP) in ICC/IF

Product Details

12834-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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