Invitrogen

HDAC6 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-85101

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human HDAC6. The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2792249

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Rhesus Monkey (100%).

Positive Control: 3xFlag-human HDAC6-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ16239; HD6; HDA6; Histone deacetylase 6; Protein deacetylase HDAC6; protein phosphatase 1, regulatory subunit 90; Tubulin-lysine deacetylase HDAC6

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Gene Aliases: CPBHM; HD6; HDAC6; JM21; KIAA0901; PPP1R90

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UniProt ID: (Human) Q9UBN7

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Entrez Gene ID: (Human) 10013

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Function(s)
core promoter binding actin binding histone deacetylase activity protein binding beta-catenin binding microtubule binding zinc ion binding enzyme binding polyubiquitin binding ubiquitin protein ligase binding NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase binding tubulin deacetylase activity alpha-tubulin binding tau protein binding beta-tubulin binding misfolded protein binding Hsp90 protein binding dynein complex binding
Process(es)
protein polyubiquitination transcription, DNA-templated protein deacetylation misfolded or incompletely synthesized protein catabolic process intracellular protein transport organelle organization negative regulation of microtubule depolymerization response to toxic substance positive regulation of signal transduction response to organic substance regulation of receptor activity regulation of autophagy positive regulation of epithelial cell migration negative regulation of hydrogen peroxide metabolic process positive regulation of receptor biosynthetic process macroautophagy histone deacetylation regulation of protein stability lysosome localization peptidyl-lysine deacetylation cellular response to topologically incorrect protein regulation of gene expression, epigenetic ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein complex disassembly negative regulation of protein complex disassembly regulation of fat cell differentiation negative regulation of proteolysis negative regulation of transcription, DNA-templated negative regulation of oxidoreductase activity mitochondrion localization response to misfolded protein regulation of microtubule-based movement regulation of androgen receptor signaling pathway regulation of establishment of protein localization cellular response to hydrogen peroxide aggresome assembly polyubiquitinated misfolded protein transport Hsp90 deacetylation response to growth factor histone H3 deacetylation cellular response to misfolded protein positive regulation of chaperone-mediated protein complex assembly tubulin deacetylation mitophagy in response to mitochondrial depolarization positive regulation of hydrogen peroxide-mediated programmed cell death regulation of mitophagy
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