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OriGene
HDAC6 Monoclonal Antibody (OTI4C5), TrueMAB™
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Product Details
CF502030
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4C5
Immunogen
Full length human recombinant protein of human HDAC6 produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ16239; HD6; HDA6; Histone deacetylase 6; Protein deacetylase HDAC6; protein phosphatase 1, regulatory subunit 90; Tubulin-lysine deacetylase HDAC6
Gene Aliases: CPBHM; HD6; HDAC6; JM21; KIAA0901; PPP1R90
UniProt ID: (Human) Q9UBN7
Entrez Gene ID: (Dog) 480907, (Human) 10013, (Rat) 84581
core promoter binding
actin binding
histone deacetylase activity
protein binding
beta-catenin binding
microtubule binding
zinc ion binding
enzyme binding
polyubiquitin binding
ubiquitin protein ligase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase binding
tubulin deacetylase activity
alpha-tubulin binding
tau protein binding
beta-tubulin binding
misfolded protein binding
Hsp90 protein binding
dynein complex binding
hydrolase activity
ubiquitin binding
protein polyubiquitination
regulation of protein phosphorylation
response to amphetamine
protein deacetylation
ubiquitin-dependent protein catabolic process
misfolded or incompletely synthesized protein catabolic process
intracellular protein transport
negative regulation of microtubule depolymerization
metabolic process
positive regulation of cell proliferation
response to toxic substance
positive regulation of signal transduction
response to organic substance
regulation of receptor activity
positive regulation of epithelial cell migration
regulation of mitochondrion organization
positive regulation of receptor biosynthetic process
negative regulation of neuron projection development
macroautophagy
histone deacetylation
axonal transport of mitochondrion
neuron differentiation
lysosome localization
cellular response to oxidative stress
peptidyl-lysine deacetylation
response to immobilization stress
cellular response to topologically incorrect protein
regulation of gene expression, epigenetic
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein complex disassembly
negative regulation of protein complex disassembly
regulation of fat cell differentiation
negative regulation of proteolysis
negative regulation of axon extension involved in axon guidance
positive regulation of dendrite morphogenesis
response to corticosterone
response to misfolded protein
positive regulation of synaptic transmission, glutamatergic
regulation of establishment of protein localization
cellular response to hydrogen peroxide
regulation of microtubule cytoskeleton organization
aggresome assembly
polyubiquitinated misfolded protein transport
Hsp90 deacetylation
response to growth factor
cellular response to misfolded protein
cellular response to parathyroid hormone stimulus
response to dexamethasone
positive regulation of chaperone-mediated protein complex assembly
tubulin deacetylation
positive regulation of tubulin deacetylation
positive regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of protein acetylation
positive regulation of oxidative stress-induced neuron death
transcription, DNA-templated
organelle organization
regulation of autophagy
negative regulation of hydrogen peroxide metabolic process
regulation of protein stability
negative regulation of transcription, DNA-templated
negative regulation of oxidoreductase activity
mitochondrion localization
regulation of microtubule-based movement
regulation of androgen receptor signaling pathway
histone H3 deacetylation
mitophagy in response to mitochondrial depolarization
regulation of mitophagy
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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