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HDAC7 Antibody (A301-385A) in IHC (P)
Detection of human and mouse HDAC7 by immunohistochemistry. Sample: FFPE section of human prostate carcinoma (left) and mouse colon carcinoma (right). Antibody: Affinity purified rabbit anti-HDAC7 (Product # A301-385A) (Lot 1) used at a dilution of 1:5,000 (0.2 µg/mL) and 1:1,000 (1 µg/mL). Detection: DAB.
Product Details
A301-385A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 902 and 952 of human histone deacetylase 7A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HD7; HD7a; hdac-7; Histone deacetylase 7; Histone deacetylase 7A; Protein deacetylase HDAC7
Gene Aliases: HD7; HD7A; HDAC7; HDAC7A
UniProt ID: (Human) Q8WUI4
Entrez Gene ID: (Human) 51564
chromatin binding
transcription corepressor activity
protein kinase C binding
protein binding
SUMO transferase activity
protein kinase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
activating transcription factor binding
metal ion binding
repressing transcription factor binding
14-3-3 protein binding
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
transcription, DNA-templated
cell-cell junction assembly
chromatin modification
protein sumoylation
neuron differentiation
negative regulation of interleukin-2 production
negative regulation of osteoblast differentiation
neuron apoptotic process
histone H3 deacetylation
cellular response to mechanical stimulus
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of neuron death
negative regulation of NIK/NF-kappaB signaling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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