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Invitrogen
HDAC7 Recombinant Rabbit Monoclonal Antibody (SD082-4)
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Product Details
MA5-32386
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SD082-4
Immunogen
Recombinant protein within Human HDAC7 aa 1-218
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809666
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HD7; HD7a; hdac-7; Histone deacetylase 7; Histone deacetylase 7A; Protein deacetylase HDAC7
Gene Aliases: 5830434K02Rik; HD7; HD7A; HDAC7; HDAC7A; mFLJ00062
UniProt ID: (Human) Q8WUI4, (Mouse) Q8C2B3
Entrez Gene ID: (Human) 51564, (Mouse) 56233, (Rat) 84582
chromatin binding
transcription corepressor activity
protein kinase C binding
protein binding
SUMO transferase activity
protein kinase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
activating transcription factor binding
metal ion binding
repressing transcription factor binding
14-3-3 protein binding
histone deacetylase activity
transcription factor binding
hydrolase activity
histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K18 specific)
molecular_function
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
inflammatory response
cell-cell junction assembly
nervous system development
chromatin modification
histone deacetylation
B cell differentiation
negative regulation of interleukin-2 production
B cell activation
negative regulation of osteoblast differentiation
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of neuron death
chromatin organization
neuron differentiation
neuron apoptotic process
histone H3-K9 modification
histone H3 deacetylation
histone H4 deacetylation
cellular response to mechanical stimulus
protein sumoylation
negative regulation of NIK/NF-kappaB signaling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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