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Product Details
11077-100UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Plant,
Yeast
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2-E7
Immunogen
Synthetic peptide corresponding to the C-terminus of yeast Bip.
Conjugate
Form
Liquid
Concentration
0.5-1.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
HSP 70 family comprises four highly conserved proteins, HSP 70, HSC 70, GRP 75 and GRP 78, which serve a variety of roles. They act as molecular chaperones, facilitating the assembly of multi-protein complexes; participate in the translocation of polypeptides across cell membranes and to the nucleus; and aid in the proper folding of nascent polypeptide chains. GRP 78 is localized in the endoplasmic reticulum (ER), where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually KDEL in animal cells, and HDEL in S.cerevisiae. The 2E7 clone recognizes the C-terminal peptide HDEL, a common version of the endoplasmic reticulum retention signal found in yeast, plant, nematode and other ER proteins. 2E7 specifically stains HDEL proteins in barnyard grass, beet, cotton, mung bean, sorghum and wheat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG5183-PA; CG5183-PB; CG5183-PC; ER lumen protein retaining receptor 2; ER lumen protein-retaining receptor; KDEL receptor; KDEL-receptor; KdelR-PA; KdelR-PB; KdelR-PC; KDELR1; lethal (2) 31Em
Gene Aliases: BEST:CK00230; CG5183; CK00230; Dmel\CG5183; Dmel_CG5183; dmErd2; ERD2; KdelR; l(2)31Em; l(2)k00311
UniProt ID: (Fruit fly) O76767
Entrez Gene ID: (Fruit fly) 34427
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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