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Invitrogen
HELT Polyclonal Antibody
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Product Details
PA5-48608
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 131-160 amino acids from the Central region of human HELT.
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2634065
Product Specific Information
Predicted to react with zebrafish based on sequence homology.
Target Information
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLH transcription factor megane; Hairy and enhancer of split-related protein HELT; HES/HEY-like transcription factor; Heslike; Hey-like transcription factor; Hey-like transcriptional repressor; Megane bHLH factor; mesencephalic GABAergic neurons enhancer of split related protein; Protein Hes-like; Protein megane
Gene Aliases: A830086M02; bHLHb44; HCM1228; HELT; HESL; megane; Mgn
UniProt ID: (Human) A6NFD8, (Mouse) Q7TS99
Entrez Gene ID: (Human) 391723, (Mouse) 234219
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein homodimerization activity
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
negative regulation of transcription from RNA polymerase II promoter
suckling behavior
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
nervous system development
central nervous system development
post-embryonic development
multicellular organism aging
gene expression
GABAergic neuron differentiation in basal ganglia
cell differentiation
neuron differentiation
multicellular organism growth
positive regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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