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Product Details
PA5-76129
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of human HERV-FRD.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719856
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endogenous retrovirus group FRD member 1; endogenous retrovirus group FRD, member 1; envelope glycoprotein syncytin-A; envelope glycoprotein syncytin-B; Envelope polyprotein; FLJ41944; FLJ90611; HERV-FRD; HERV-FRD provirus ancestral Env polyprotein; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; MGC87585; placenta-specific/fusogenic; Synb; syncytin 2; Syncytin-2; Syncytin-B; Syncytin2
Gene Aliases: D930020E02Rik; envFRD; ERVFRD-1; ERVFRDE1; GLLL6191; Gm52; HERV-FRD; HERV-W/FRD; Synb; syncytin-B; UNQ6191; UNQ6191/PRO20218
UniProt ID: (Human) P60508, (Mouse) Q8BI41
Entrez Gene ID: (Human) 405754, (Rat) 288602, (Mouse) 239167
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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