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Proteintech
HEXA Monoclonal Antibody (3A4F2)
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Product Details
60337-1-IG
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3A4F2
Immunogen
HEXA Fusion Protein Ag1854 (1-529 aa encoded by BC018927)
Conjugate
Form
Liquid
Concentration
1.86 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTSSRLWFS LLLAAAFAGR ATALWPWPQN FQTSDQRYVL YPNNFQFQYD VSSAAQPGCS VLDEAFQRYR DLLFGSGSWP RPYLTGKRHT LEKNVLVVSV VTPGCNQLPT LESVENYTLT INDDQCLLLS ETVWGALRGL ETFSQLVWKS AEGTFFINKT EIEDFPRFPH RGLLLDTSRH YLPLSSILDT LDVMAYNKLN VFHWHLVDDP SFPYESFTFP ELMRKGSYNP VTHIYTAQDV KEVIEYARLR GIRVLAEFDT PGHTLSWGPG IPGLLTPCYS GSEPSGTFGP VNPSLNNTYE FMSTFFLEVS SVFPDFYLHL GGDEVDFTCW KSNPEIQDFM RKKGFGEDFK QLESFYIQTL LDIVSSYGKG YVVWQEVFDN KVKIQPDTII QVWREDIPVN YMKELELVTK AGFRALLSAP WYLNRISYGP DWKDFYVVEP LAFEGTPEQK ALVIGGEACM WGEYVDNTNL VPRLWPRAGA VAERLWSNKL TSDLTFAYER LSHFRCELLR RGVQAQPLNV GFCEQEFEQT (1-529 aa encoded by BC018927)
Target Information
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-hexosaminidase alpha-subunit; Beta-hexosaminidase subunit alpha; Beta-N-acetylhexosaminidase subunit alpha; EC 3.2.1; EC 3.2.1.52; hexosaminidase A (alpha polypeptide); Hexosaminidase subunit A; Hexose aminidase A (alpha polypeptide); MGC99608; N-acetyl-beta-glucosaminidase subunit alpha
Gene Aliases: Hex-1; HEXA; TSD
UniProt ID: (Human) P06865, (Mouse) P29416, (Rat) Q641X3
Entrez Gene ID: (Rabbit) 100008950, (Human) 3073, (Mouse) 15211, (Rat) 300757
skeletal system development
carbohydrate metabolic process
ganglioside catabolic process
lysosome organization
sensory perception of sound
locomotory behavior
adult walking behavior
metabolic process
lipid storage
sexual reproduction
glycosaminoglycan metabolic process
myelination
cell morphogenesis involved in neuron differentiation
neuromuscular process controlling posture
neuromuscular process controlling balance
SMAD protein signal transduction
glycosaminoglycan biosynthetic process
glycosphingolipid metabolic process
chondroitin sulfate catabolic process
hyaluronan catabolic process
keratan sulfate catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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