Proteintech

HEXB Polyclonal Antibody

HEXB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HEXB Antibody (16229-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney using 16229-1-AP (HEXB antibody) at dilution of 1:50 (under 40x lens).

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Product Details

16229-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HEXB Fusion Protein Ag8683 (1-332 aa encoded by BC017378)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MELCGLGLP RPPMLLALLL ATLLAAMLAL LTQVALVVQV AEAARAPSVS AKPGPALWPL PLSVKMTPNL LHLAPENFYI SHSPNSTAGP SCTLLEEAFR RYHGYIFGFY KWHHEPAEFQ AKTQVQQLLV SITLQSECDA FPNISSDESY TLLVKEPVAV LKANRVWGAL RGLETFSQLV YQDSYGTFTI NESTIIDSPR FSHRGILIDT SRHYLPVKII LKTLDAMAFN KFNVLHWHIV DDQSFPYQSI TFPELSNKGS YSLSHVYTPN DVRMVIEYAR LRGIRVLPEF DTPGHTLSWG KGQKDLLTPC YSRQNKLDSF GPINPTLNTT YSF (1-332 aa encoded by BC017378)

Target Information

Hexosaminidase B (HEXB), also designated beta-hexosaminidase B, is a Hexosaminidase B (HEXB), also designated b-hexosaminidase B, is a tetramer of two b-A and two b-B chains and is found in the lysosomes of cells. Sandhoff disease (SD), also known as GM2-gangliosidosis type II, is caused by mutations in the HEXB gene that affect the b subunit. These mutations disrupt the activity of HEXB and HEXA, which prevents the breakdown of GM2 ganglioside, a fatty material found in the brain, therby rendering both the HEXA and HEXB enzymes deficient. SD is a rare autosomal recessive disorder characterized by an accumulation of GM2 ganglioside, which causes progressive destruction of the central nervous system. Sandhoff disease is similar to Tay-Sachs disease, which is caused by mutations in the HEXA gene, although SD is more severe.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Characteristics of activation of monocyte-derived macrophages versus microglia after mouse experimental intracerebral hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Ye F,Yang J,Holste KG,Koduri S,Hua Y,Keep RF,Garton HJ,Xi G

Fri Sep 01 00:00:00 UTC 2023

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.

Nature communications

Boland S,Swarup S,Ambaw YA,Malia PC,Richards RC,Fischer AW,Singh S,Aggarwal G,Spina S,Nana AL,Grinberg LT,Seeley WW,Surma MA,Klose C,Paulo JA,Nguyen AD,Harper JW,Walther TC,Farese RV

Fri Oct 07 00:00:00 UTC 2022

Identification and Validation of a Nine-Gene Amino Acid Metabolism-Related Risk Signature in HCC.

Frontiers in cell and developmental biology

Zhao Y,Zhang J,Wang S,Jiang Q,Xu K

Sat Sep 25 00:00:00 UTC 2021

Identification and Validation of a Nine-Gene Amino Acid Metabolism-Related Risk Signature in HCC.

Frontiers in cell and developmental biology

Zhao Y,Zhang J,Wang S,Jiang Q,Xu K

Sat Sep 25 00:00:00 UTC 2021

Microglia-Specific Expression of HEXA and HEXB Leads to Poor Prognosis in Glioblastoma Patients.

Frontiers in oncology

Jia M,Zhang W,Zhu J,Huang C,Zhou J,Lian J,Wang Y,Teng H,Huang Z

Tue Aug 24 00:00:00 UTC 2021

Microglia-Specific Expression of HEXA and HEXB Leads to Poor Prognosis in Glioblastoma Patients.

Frontiers in oncology

Jia M,Zhang W,Zhu J,Huang C,Zhou J,Lian J,Wang Y,Teng H,Huang Z

Tue Aug 24 00:00:00 UTC 2021

Microglia-Specific Expression of HEXA and HEXB Leads to Poor Prognosis in Glioblastoma Patients.

Frontiers in oncology

Jia M,Zhang W,Zhu J,Huang C,Zhou J,Lian J,Wang Y,Teng H,Huang Z

Tue Aug 24 00:00:00 UTC 2021

The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain.

Molecular neurobiology

Sims-Robinson C,Bakeman A,Rosko A,Glasser R,Feldman EL

Sun May 01 00:00:00 UTC 2016

The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain.

Molecular neurobiology

Sims-Robinson C,Bakeman A,Rosko A,Glasser R,Feldman EL

Sun May 01 00:00:00 UTC 2016

Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.

Biology open

Bastow ER,Last K,Golub S,Stow JL,Stanley AC,Fosang AJ

Sun Apr 15 00:00:00 UTC 2012

Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.

Biology open

Bastow ER,Last K,Golub S,Stow JL,Stanley AC,Fosang AJ

Sun Apr 15 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: Beta-hexosaminidase subunit beta; Beta-N-acetylhexosaminidase subunit beta; Cervical cancer proto-oncogene 7 protein; epididymis luminal protein 248; epididymis secretory protein Li 111; HCC-7; hexosaminidase B (beta polypeptide); Hexosaminidase subunit B; N-acetyl-beta-glucosaminidase subunit beta

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Gene Aliases: ENC-1AS; HCC7; HEL-248; HEL-S-111; HEXB

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UniProt ID: (Human) P07686, (Mouse) P20060, (Rat) Q6AXR4

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Entrez Gene ID: (Human) 3074, (Mouse) 15212, (Rat) 294673

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Function(s)

beta-N-acetylhexosaminidase activity acetylglucosaminyltransferase activity protein homodimerization activity protein heterodimerization activity hydrolase activity, hydrolyzing O-glycosyl compounds hexosaminidase activity beta-N-acetylglucosaminidase activity hydrolase activity hydrolase activity, acting on glycosyl bonds carbohydrate binding

Process(es)

skeletal system development carbohydrate metabolic process N-acetylglucosamine metabolic process glycosphingolipid metabolic process ganglioside catabolic process cellular calcium ion homeostasis lysosome organization single fertilization penetration of zona pellucida sensory perception of sound locomotory behavior male courtship behavior metabolic process regulation of cell shape phospholipid biosynthetic process oligosaccharide catabolic process lipid storage sexual reproduction glycosaminoglycan metabolic process regulation of cellular metabolic process myelination astrocyte cell migration cellular protein metabolic process positive regulation of transcription from RNA polymerase II promoter oogenesis neuromuscular process controlling balance neuromuscular process chondroitin sulfate catabolic process hyaluronan catabolic process keratan sulfate catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HEXB Polyclonal Antibody

HEXB Antibody (16229-1-AP) in IHC (P)

Product Details

16229-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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