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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • HEY1 Antibodies

          Proteintech

          HEY1 Polyclonal Antibody

          48 References
          View all (23) HEY1 antibodies

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          Cite HEY1 Polyclonal Antibody

          • Antibody Testing Data (10)
          HEY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          HEY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 10

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          HEY1 Antibody (19929-1-AP) in IHC (P)

          Immunohistochemistry of paraffin-embedded human kidney using 19929-1-AP (HEY1 antibody) at dilution of 1:200 (under 40x lens). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          HEY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HEY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HEY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HEY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HEY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HEY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HEY1 Antibody in Western Blot (WB)
          HEY1 Antibody in Western Blot (WB)
          HEY1 Antibody in Western Blot (WB)
          HEY1 Antibody in Immunoprecipitation (IP)

          Product Details

          19929-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 35 publications 35 publications

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunocytochemistry (ICC/IF)

          -
          View 3 publications 3 publications

          Flow Cytometry (Flow)

          -
          View 1 publication 1 publication

          Immunoprecipitation (IP)

          0.5-4.0 µg
          View 2 publications 2 publications

          ChIP assay (ChIP)

          -
          View 3 publications 3 publications

          Miscellaneous PubMed (MISC)

          -
          View 1 publication 1 publication

          Not applicable (N/A)

          -
          View 2 publications 2 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          HEY1 Fusion Protein Ag13906 (155-295 aa encoded by BC001873)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.31 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: VSHLNNYAS QREAASGAHA GLGHIPWGTV FGHHPHIAHP LLLPQNGHGN AGTTASPTEP HHQGRLGSAH PEAPALRAPP SGSLGPVLPV VTSASKLSPP LLSSVASLSA FPFSFGSFHL LSPNALSPSA PTQAANLGKP YR (155-295 aa encoded by BC001873)

          Target Information

          Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: basic helix-loop-helix protein OAF1; bHLHb31; Cardiovascular helix-loop-helix factor 2; CHF-2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split-related protein 1; Hairy-related transcription factor 1; Hairy/E(spl)-related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif 1; Hairy/enhancer-of-split related with YRPW motif protein 1; hes-related family bHLH transcription factor with YRPW motif 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-1; HRT-1; MGC1274; mHRT1

          View more View less

          Gene Aliases: AI316788; AI414254; BHLHB31; CHF2; HERP2; hesr-1; HESR1; HEY1; hHRT1; HRT-1; HRT1; OAF1

          View more View less

          UniProt ID: (Human) Q9Y5J3

          View more View less

          Entrez Gene ID: (Human) 23462, (Mouse) 15213, (Rat) 155437

          View more View less

          Function(s)
          transcription factor activity, RNA polymerase II core promoter sequence-specific transcription factor activity, protein binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding microsatellite binding protein dimerization activity transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding sequence-specific DNA binding molecular_function
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter blood vessel development vasculogenesis osteoblast development outflow tract morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis atrioventricular valve formation epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion to mesenchymal transition involved in heart valve formation endocardial cushion morphogenesis cardiac ventricle morphogenesis ventricular trabecula myocardium morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development anterior/posterior axis specification negative regulation of gene expression mesenchymal cell development dorsal aorta morphogenesis umbilical cord morphogenesis negative regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cardiac epithelial to mesenchymal transition cardiac septum morphogenesis ventricular septum morphogenesis labyrinthine layer blood vessel development artery development arterial endothelial cell differentiation Notch signaling involved in heart development negative regulation of transcription regulatory region DNA binding negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation regulation of vasculogenesis angiogenesis cellular response to glucocorticoid stimulus heart trabecula formation
          It has to be done as per old AB suggested Products section.
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