Invitrogen

HFE Polyclonal Antibody

View all (16) HFE antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-84157

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HFE. Recombinant protein control fragment (Product #RP-103158).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2791309

Product Specific Information

Immunogen sequence: LGLSLFEALG YVDDQLFVFY DHESRRVEPR TPWVSSRISS QMWLQLSQSL KGWDHMFTVD FWTIMENHNH SKESHTLQVI LGCEMQEDNS TEGYWKYGYD GQDHLEFCPD TLDWRAAEPR AWPTKLEWE

Target Information

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin. It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Hereditary hemochromatosis protein; hereditary hemochromatosis protein HLA-H; HFE 1; high Fe; HLA H; HLA-H; MGC10379; MGC103790; MGC:150812; MHC class I-like protein HFE

View more View less

Gene Aliases: HFE; HFE1; HH; HLA-H; HLAH; MVCD7; TFQTL2

View more View less

UniProt ID: (Human) Q30201

View more View less

Entrez Gene ID: (Human) 3077

View more View less

Function(s)
antigen binding receptor binding protein binding beta-2-microglobulin binding co-receptor binding peptide antigen binding transferrin receptor binding
Process(es)
antigen processing and presentation of peptide antigen via MHC class I negative regulation of T cell antigen processing and presentation negative regulation of T cell cytokine production protein complex assembly cellular iron ion homeostasis acute-phase response immune response female pregnancy response to iron ion cellular response to iron ion starvation positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation antigen processing and presentation BMP signaling pathway positive regulation of protein binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process hormone biosynthetic process positive regulation of receptor-mediated endocytosis iron ion homeostasis multicellular organismal iron ion homeostasis cellular response to iron ion positive regulation of peptide hormone secretion liver regeneration iron ion import into cell negative regulation of receptor binding positive regulation of receptor binding positive regulation of ferrous iron import into cell negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I positive regulation of ferrous iron binding positive regulation of transferrin receptor binding response to iron ion starvation regulation of protein localization to cell surface negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of receptor activity positive regulation of receptor activity negative regulation of CD8-positive, alpha-beta T cell activation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support