Invitrogen

HFE Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-88983

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 80-306 of human HFE (NP_0004011)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.40 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2805271

Product Specific Information

Immunogen sequence: SSQMWLQLSQ SLKGWDHMFT VDFWTIMENH NHSKESHTLQ VILGCEMQED NSTEGYWKYG YDGQDHLEFC PDTLDWRAAE PRAWPTKLEW ERHKIRARQN RAYLERDCPA QLQQLLELGR GVLDQQVPPL VKVTHHVTSS VTTLRCRALN YYPQNITMKW LKDKQPMDAK EFEPKDVLPN GDGTYQGWIT LAVPPGEEQR YTCQVEHPGL DQPLIVIWEP SPSGTLV; Positive Samples: Mouse liver, Mouse heart; Cellular Location: Cell membrane, Single-pass type I membrane protein

Target Information

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin. It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Hereditary hemochromatosis protein; hereditary hemochromatosis protein HLA-H; Hereditary hemochromatosis protein homolog; HFE 1; high Fe; HLA H; HLA-H; MGC10379; MGC103790; MGC:150812; MHC class I-like protein HFE

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Gene Aliases: HFE; HFE1; HH; HLA-H; HLAH; MR2; MVCD7; TFQTL2

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UniProt ID: (Human) Q30201, (Mouse) P70387

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Entrez Gene ID: (Human) 3077, (Mouse) 15216

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Function(s)
antigen binding receptor binding protein binding beta-2-microglobulin binding co-receptor binding peptide antigen binding transferrin receptor binding
Process(es)
immune system process antigen processing and presentation of peptide antigen via MHC class I immune response positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation antigen processing and presentation BMP signaling pathway negative regulation of proteasomal ubiquitin-dependent protein catabolic process hormone biosynthetic process iron ion homeostasis multicellular organismal iron ion homeostasis iron ion import into cell negative regulation of receptor binding negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of T cell antigen processing and presentation negative regulation of T cell cytokine production protein complex assembly cellular iron ion homeostasis acute-phase response female pregnancy response to iron ion cellular response to iron ion starvation positive regulation of protein binding positive regulation of receptor-mediated endocytosis cellular response to iron ion positive regulation of peptide hormone secretion liver regeneration positive regulation of receptor binding positive regulation of ferrous iron import into cell negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I positive regulation of ferrous iron binding positive regulation of transferrin receptor binding response to iron ion starvation regulation of protein localization to cell surface negative regulation of receptor activity positive regulation of receptor activity negative regulation of CD8-positive, alpha-beta T cell activation
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