Proteintech

HGF alpha Polyclonal Antibody

HGF alpha Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HGF alpha Antibody (26881-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 26881-1-AP (HGF alpha antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

26881-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HGF alpha Fusion Protein Ag25456 (118-157 aa encoded by BC130286)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LYENKDYIR NCIIGKGRSY KGTVSITKSG IKCQPWSSMI P (118-157 aa encoded by BC130286)

Target Information

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Interferon gamma regulates a complex pro-survival signal network in chronic lymphocytic leukemia.

European journal of haematology

Chen Y,Shao X,Yang H,Ren L,Cui Y,Zhang W,Macip S,Meng X

Sat Apr 01 00:00:00 UTC 2023

Silencing CircEIF3I/miR-526b-5p Axis Epigenetically Targets HGF/c-Met Signal to Hinder the Malignant Growth, Metastasis and Angiogenesis of Hepatocellular Carcinoma.

Biochemical genetics

Liu Y,Xiao X,Wang J,Wang Y,Yu Y

Wed Feb 01 00:00:00 UTC 2023

Therapeutic Efficiency of Nasal Mucosa-Derived Ectodermal Mesenchymal Stem Cells in Rats with Acute Hepatic Failure.

Stem cells international

Xiang W,Wang X,Yu X,Xie Y,Zhang L,Lu N,Jiang W

Fri Jan 20 00:00:00 UTC 2023

Loss of MEN1 leads to renal fibrosis and decreases HGF-Adamts5 pathway activity via an epigenetic mechanism.

Clinical and translational medicine

Jin B,Zhu J,Zhou Y,Liang L,Yang Y,Xu L,Zhang T,Li P,Pan T,Guo B,Chen T,Li H

Mon Aug 01 00:00:00 UTC 2022

Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections.

Journal of controlled release : official journal of the Controlled Release Society

Wang Y,Liu S,Li L,Li L,Zhou X,Wan M,Lou P,Zhao M,Lv K,Yuan Y,Chen Y,Lu Y,Cheng J,Liu J

Thu Sep 01 00:00:00 UTC 2022

Improving the circulation time and renal therapeutic potency of extracellular vesicles using an endogenous ligand binding strategy.

Journal of controlled release : official journal of the Controlled Release Society

Liu S,Lv K,Wang Y,Lou P,Zhou P,Wang C,Li L,Liao G,Zhang Y,Chen Y,Cheng J,Lu Y,Liu J

Thu Dec 01 00:00:00 UTC 2022

Hepatocyte Growth Factor Overexpression Slows the Progression of 4NQO-Induced Oral Tumorigenesis.

Frontiers in oncology

He X,Chen S,Tang Y,Zhao X,Yan L,Wu L,Wu Z,Liu W,Chen X,Wang X

Fri Apr 29 00:00:00 UTC 2022

Serum proteome profiling provides a deep understanding of the 'gut-liver axis' in relation to liver injury and regeneration.

Acta biochimica et biophysica Sinica

Leng L,Ma J,Lv L,Gao D,Li M,Wang Y,Zhu Y

Tue Mar 02 00:00:00 UTC 2021

Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.

Clinical and translational medicine

Dong X,Luo Y,Lu S,Ma H,Zhang W,Zhu Y,Sun G,Sun X

Mon Feb 01 00:00:00 UTC 2021

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.

ACS nano

Zhao M,Liu S,Wang C,Wang Y,Wan M,Liu F,Gong M,Yuan Y,Chen Y,Cheng J,Lu Y,Liu J

Tue Jan 26 00:00:00 UTC 2021

Sushi Repeat Containing Protein X-linked 2 Is a Downstream Signal of LEM Domain Containing 1 and Acts as a Tumor-Promoting Factor in Oral Squamous Cell Carcinoma.

International journal of molecular sciences

Sasahira T,Kurihara-Shimomura M,Nishiguchi Y,Shimomura H,Kirita T

Fri May 22 00:00:00 UTC 2020

Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors.

Food & function

Xing M,Fu R,Liu Y,Wang P,Ma P,Zhu C,Fan D

Fri May 01 00:00:00 UTC 2020

Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis.

Stem cell research & therapy

Dong X,Kong F,Liu C,Dai S,Zhang Y,Xiao F,Zhang H,Wu CT,Wang H

Wed Jun 10 00:00:00 UTC 2020

Therapeutic activity of DCC-2036, a novel tyrosine kinase inhibitor, against triple-negative breast cancer patient-derived xenografts by targeting AXL/MET.

International journal of cancer

Shen Y,Zhang W,Liu J,He J,Cao R,Chen X,Peng X,Xu H,Zhao Q,Zhong J,Ding W,Lei X,Jiang Y,Zu X

Fri Feb 01 00:00:00 UTC 2019

Therapeutic activity of DCC-2036, a novel tyrosine kinase inhibitor, against triple-negative breast cancer patient-derived xenografts by targeting AXL/MET.

International journal of cancer

Shen Y,Zhang W,Liu J,He J,Cao R,Chen X,Peng X,Xu H,Zhao Q,Zhong J,Ding W,Lei X,Jiang Y,Zu X

Fri Feb 01 00:00:00 UTC 2019

Cx32 mediates norepinephrine-promoted EGFR-TKI resistance in a gap junction-independent manner in non-small-cell lung cancer.

Journal of cellular physiology

Xie J,Wang X,Ge H,Peng F,Zheng N,Wang Q,Tao L

Sun Dec 01 00:00:00 UTC 2019

ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma.

Cancer research

Capparelli C,Purwin TJ,Heilman SA,Chervoneva I,McCue PA,Berger AC,Davies MA,Gershenwald JE,Krepler C,Aplin AE

Mon Oct 01 00:00:00 UTC 2018

ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma.

Cancer research

Capparelli C,Purwin TJ,Heilman SA,Chervoneva I,McCue PA,Berger AC,Davies MA,Gershenwald JE,Krepler C,Aplin AE

Mon Oct 01 00:00:00 UTC 2018

Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling.

Stem cells international

Luo YH,Chen J,Xiao EH,Li QY,Luo YM

Thu Sep 28 00:00:00 UTC 2023

Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling.

Stem cells international

Luo YH,Chen J,Xiao EH,Li QY,Luo YM

Thu Sep 28 00:00:00 UTC 2023

Clinicopathologic Features and Prognostic Factors in Alpha-Fetoprotein-Producing Colorectal Cancer: Analysis of 78 Cases.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Feng Y,Li Y,Dai W,Mo S,Li Q,Cai S

Fri Jan 25 00:00:00 UTC 2019

Clinicopathologic Features and Prognostic Factors in Alpha-Fetoprotein-Producing Colorectal Cancer: Analysis of 78 Cases.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Feng Y,Li Y,Dai W,Mo S,Li Q,Cai S

Fri Jan 25 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Fibroblast derived tumor cytotoxic factor; fibroblast-derived tumor cytotoxic factor; Hepatocyte growth factor; Hepatocyte growth factor (hepapoietin A; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatopoeitin A; Hepatopoietin-A; HepatopoietinA; Lung fibroblast derived mitogen; lung fibroblast-derived mitogen; Scatter factor; scatter factor); SF

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Gene Aliases: DFNB39; F-TCF; HGF; HGFB; HPTA; SF

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UniProt ID: (Human) P14210

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Entrez Gene ID: (Human) 3082

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Function(s)

serine-type endopeptidase activity protein binding growth factor activity chemoattractant activity protein heterodimerization activity

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HGF alpha Polyclonal Antibody

HGF alpha Antibody (26881-1-AP) in IHC (P)

Product Details

26881-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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