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Abnova
HHATL Monoclonal Antibody (2B7)
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Product Details
H00057467-M07A
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2B7
Immunogen
HHATL (NP_065758.2, 157 a.a. approximately 206 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: LISWQSGFVT GTFDLQEVLF HGGSSFTVLR CTSFALESCA HPDRHYSLAD
Target Information
The Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL), also known at the mammalian glycerol uptake/transporter 1 (Gup1) is a homolog of the S. cerevisiae Gup1. It is an endoplasmic reticulum (ER) membrane protein that co-localizes with the mammalian hedgehog acyltransferse Skn and interferes with its N-terminal palmitoylation of Sonic hedgehog (SHH), suggesting that HHATL acts as a negative regulator for N-terminal palmitoylation of SHH. HHATL is highly expressed in normal skin, but becomes down-regulated in skin squamous cell carcinoma, suggesting it may play a role in its development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycerol uptake/transporter homolog; GUP1 glycerol uptake/transporter homolog; Hedgehog acyltransferase-like protein; membrane bound O-acyltransferase domain containing 3; Protein-cysteine N-palmitoyltransferase HHAT-like protein
Gene Aliases: C3orf3; GUP1; HHATL; KIAA1173; MBOAT3; MSTP002; OACT3
UniProt ID: (Human) Q9HCP6
Entrez Gene ID: (Human) 57467
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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