Bioss

HHEX Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-6600R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human HHEX, amino acids 131-230.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

HHEX is a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. Establishes anterior identity at two levels 1) acts early to enhance canonical WNT-signaling by repressing expression of TLE4 and 2) acts later to inhibit NODAL-signaling by directly targeting NODAL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hematopoietically expressed homeobox, related sequence 2; Hematopoietically-expressed homeobox protein HHEX; homeobox; Homeobox protein HEX; Homeobox protein PRH; homeobox, hematopoietically expressed; mHex; Proline-rich homeodomain protein; proline-rich homeodomain-containing transcription factor

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Gene Aliases: HEX; Hex1; HHEX; Hhex-rs2; HMPH; HOX11L-PEN; PRH; PRHX

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UniProt ID: (Human) Q03014, (Mouse) P43120

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Entrez Gene ID: (Human) 3087, (Rat) 79237, (Mouse) 15242

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding protein binding transcription factor binding eukaryotic initiation factor 4E binding DNA binding, bending TBP-class protein binding protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding repressing transcription factor binding HMG box domain binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter vasculogenesis in utero embryonic development liver development morphogenesis of an epithelium myeloid leukocyte differentiation regulation of transcription from RNA polymerase II promoter mRNA export from nucleus signal transduction endoderm development cell proliferation response to wounding organ morphogenesis anterior/posterior pattern specification negative regulation of angiogenesis poly(A)+ mRNA export from nucleus interkinetic nuclear migration hemopoiesis cell differentiation positive regulation of Wnt signaling pathway B cell differentiation thyroid gland development forebrain development negative regulation of vascular endothelial growth factor receptor signaling pathway pancreas development protein localization to nucleus embryonic heart tube development multicellular organism growth regulation of cell proliferation response to peptide hormone negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic organ development tissue morphogenesis forebrain morphogenesis primary lung bud formation common bile duct development gall bladder development hepatic duct development hepatoblast differentiation hepatocyte differentiation DNA conformation change primitive streak formation transcription, DNA-templated Notch signaling pathway negative regulation of transcription by transcription factor localization negative regulation of transcription by competitive promoter binding Wnt signaling pathway regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development
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