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Invitrogen
HIP1R Polyclonal Antibody
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FIGURE: 1 / 1
HIP1R Antibody (PA5-116542) in WB
Western blot analysis of HIP1R in extracts of various cell lines. Samples were incubated with HIP1R Polyclonal antibody (Product # PA5-116542) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-116542
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human HIP1R (NP_0039501)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901173
Product Specific Information
Positive Samples: U-87MG, 293T, HeLa, Mouse brain, Mouse spleen, Mouse liver, Rat brain
Immunogen sequence: KPVVVIPEEA PEDEEPENLI EISTGPPAGE PVVVADLFDQ TFGPPNGSVK DDRDLQIESL KREVEMLRSE LEKIKLEAQR YIAQLKSQVN ALEGELEEQR KQKQKALVDN EQLRHELAQL RAAQLEGERS QGLREEAERK ASATEARYNK LKEKHSELVH VHAELLRKNA DTAKQLTVTQ QSQEEVARVK EQLAFQVEQV KRESELKLEE KSDQLEKLKR ELEAKAGELA RAQEALSHTE QSKSELSSRL DTLSAEKDAL SGAVRQREAD LLAAQSLVRE TEAALSREQQ RSSQEQGELQ G
Target Information
Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HIP-12; HIP1-related protein; huntingtin interacting protein 12; Huntingtin-interacting protein 1-related protein; Huntingtin-interacting protein 12
Gene Aliases: AA410023; HIP12; HIP1R; HIP3; ILWEQ; KIAA0655; mKIAA0655
UniProt ID: (Human) O75146, (Mouse) Q9JKY5
Entrez Gene ID: (Human) 9026, (Mouse) 29816, (Rat) 81917
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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